Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of microcrystalline cellulose in China. With abundant experience, we warmly welcome you to wholesale bulk microcrystalline cellulose for sale here from our factory. Quality products and reasonable price are available.
What are Microcrystalline cellulose?
Microcrystalline cellulose (MCC) is mainly composed of linear polysaccharides bonded by β-1,4-glucosidic bonds. It is a white, odorless, tasteless crystalline powder composed of extremely fine short rods or powdery porous particles that can flow freely after natural cellulose is hydrolyzed by dilute acid to the limit degree of polymerization (LODP).
In general plant fibers, microcrystalline cellulose accounts for about 70%, and the other 30% is amorphous. Microcrystalline cellulose is widely used in the pharmaceutical, cosmetic, food and other industries. Different particle sizes and water contents have different characteristics and application ranges.
The particle size is generally 20~80μm, the limiting degree of polymerization (LODP) is 15~375, it is non-fibrous and has strong fluidity. It is insoluble in water, dilute acid, organic solvents and oils, partially dissolves and swells in dilute alkaline solutions, and has high reactivity in carboxymethylation, acetylation and esterification processes. Due to its special properties such as low degree of polymerization and large specific surface area, microcrystalline cellulose is widely used in medicine, food, cosmetics and other industries.
Main uses
Due to its unique structure and properties, microcrystalline cellulose is widely used as a disintegrant, stable emulsifier, etc. in the national economy sectors such as medicine and health, food and beverage, and light chemical industry. Since cellulose is widely present in nature, hundreds of billions of tons of cellulose-rich biomass residues are produced every year in the world. If these residues are well converted and utilized, they will be a rich resource. In China, with the expansion of the production scale of leather, daily chemicals, medicine, food, and chlor-alkali industries and the improvement of product grades, the demand for microcrystalline cellulose is increasing year by year, so microcrystalline cellulose has a broad market prospect. Microcrystalline cellulose has been included in the US FDA's food additive safety index (GRAS), is allowed to be used as a food additive in Europe, is included in the FDA's "Inactive Ingredients Guide", and is allowed to be used in non-injectable preparations in the UK.
Pharmaceutical industry
Microcrystalline cellulose is often used as an adsorbent, suspending agent, diluent, and disintegrant. Microcrystalline cellulose is widely used in pharmaceutical preparations, mainly as a diluent and binder in oral tablets and capsules. It can be used not only for wet granulation but also for dry direct tablet compression. It also has a certain lubrication and disintegration effect, which is very useful in tablet preparation.
Since there are hydrogen bonds between microcrystalline cellulose molecules, hydrogen bonds are associated when compressed, so it has a high degree of compressibility and is often used as an adhesive; when the compressed tablets encounter liquid, water quickly enters the tablets containing microcrystalline cellulose, and the hydrogen bonds are broken immediately, so it can be used as a disintegrant. Therefore, it is a widely used excipient in tablet production, which can improve the hardness of tablets. For example, in the preparation of rifampicin tablets, microcrystalline cellulose can be mixed with starch (mass ratio of 6.25:1) and various raw materials and then directly compressed into tablets. The product disintegrates into mist within 1 minute. Moreover, the content remains unchanged during the validity period, and the drug stability can be greatly improved. For example, due to the addition of microcrystalline cellulose, the solubility of prednisone acetate and berberine acetate (berberine hydrochloride) tablets is increased to more than 80%. When using microcrystalline cellulose as an excipient for tableting, the traditional granulation process is not required. For example, in the preparation of Kebiqing tablets, due to the addition of microcrystalline cellulose, the serious sticking phenomenon caused by the easy moisture absorption of Kebiqing wet granulation tablets is solved, and the disintegration is rapid.
Microcrystalline cellulose can also be used as a sustained-release agent for drugs. The sustained-release process is that the active substance enters the porous structure of the carrier. The active substance is contained by intermolecular hydrogen bonds and is fixed after drying. When the active substance is released, the water diffuses in the capillary system of the polymer carrier to cause swelling, and the chemical bonds between the carrier and the fixed active substance are destroyed, and the active substance is slowly released.
Microcrystalline cellulose powder can form a stable dispersion system in water. It can be combined with drugs to make creamy or suspended liquid medicines, and can also be used as capsules. Microcrystalline cellulose forms gels in water after strong stirring, and can also be used to make paste and suspension type pharmaceutical preparations.
Food industry
In the food industry, microcrystalline cellulose, as a kind of edible fiber and ideal health food additive, can maintain the stability of emulsification and foam, maintain high temperature stability, and improve the stability of liquids. It has been certified and approved by the Joint Evaluation Committee on Food Additives of the Food and Agriculture Organization of the United Nations and the World Health Organization. Corresponding fiber products have also appeared and are widely used in dairy products, frozen foods, meat products, etc.
3 Cosmetics
Microcrystalline cellulose can be used as an ingredient in the manufacture of a variety of cosmetics, skin treatment and care products, and cleaning detergents.
Characteristics
(1) The biggest application feature of microcrystalline cellulose in solid preparations is its high compressibility. Compared with other solid pharmaceutical excipients, this is because there are hydrogen bonds between microcrystalline cellulose molecules. When compressed, the hydrogen bonds are combined, so it has a high degree of compressibility and can increase the hardness of the tablet. Therefore, it is often used as a dry adhesive; at the same time, when the compressed tablet encounters liquid, water quickly enters the interior of the tablet containing microcrystalline cellulose, and the hydrogen bonds are immediately broken, so it can also be used as a disintegrant. Therefore, it is widely used in tablet production.
(2) Microcrystalline cellulose has a high water absorption capacity. On the one hand, this characteristic has good slurry absorption ability during wet granulation, and there is enough space for the use of adhesives/wetting agents, or other functional excipients can be added to the adhesive, making the operation more controllable. On the other hand, good wettability can increase the wetting uniformity of the material during the wet granulation process, which is beneficial to the granulation uniformity and the uniformity of the final product content. Thirdly, the high water absorption of microcrystalline leads to strong hygroscopicity of the preparation. The weight gain of pure microcrystalline at RH75% for 5 days exceeds 5%, and the weight gain exceeds 10% at RH92.5% for 5 days. Therefore, when the proportion of microcrystalline in the prescription is high, attention should be paid to the problem of hygroscopic stability. , under normal storage conditions, the moisture content of microcrystalline is generally around 3%~5%, and it is relatively stable;
(3) The secondary compression moldability of microcrystalline cellulose is poor, while lactose is relatively good at this time;
(4) Because microcrystalline cellulose is insoluble in water, a "bottoming out" phenomenon will occur during the dissolution process, that is, microcrystals accumulate at the bottom of the dissolution cup in the later stage of dissolution, resulting in incomplete release of API. Therefore, for poorly soluble drugs, the general microcrystalline ratio is recommended not to exceed 30%. If the bottoming out phenomenon occurs, the microcrystalline ratio can be reduced, or the dissolution speed can be increased (50-75rpm)
(5) In different types of microcrystalline cellulose systems, the general balance relationship is: the better the fluidity, the lower the moldability.
Company Introduction
Founded in 2014, YTBIO mainly supplies food additives such as Microcrystalline cellulose, herbal extracts, functional cosmetic raw materials, organic products, etc. All of our products are produced by ourselves. At present, our certificates include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, etc. All our products have been tested and we support third-party testing. We provide a variety of products, for any detailed information about the products, please click Sales@sxytbio.Com Contact us, we will have professional sales staff to give you detailed answers
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