Troxerutin Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of troxerutin powder in China. With abundant experience, we warmly welcome you to wholesale bulk troxerutin powder for sale here from our factory. Quality products and reasonable price are available.

Troxerutin powder is extracted from Sophora japonica flower. Ingredients of natural plant origin. It is one of the derivatives of flavonoids. It has a strong absorption effect on blue light, and at the same time has a good antioxidant effect, which can reduce various damages to the skin and achieve anti-blue light effects.
Troxerutin, chemical name 7,3,4,-tris(O-(2-hydroxyhexyl))rutin, is a mixture of hydroxyethylrutin obtained by hydroxyethylation of rutin , is a yellow, yellow-green or light brown powder, odorless, slightly salty, hygroscopic, and its main hydrolysis product is hyperoside. Troxerutin is a semi-synthetic flavonoid compound produced by hydroxyethylation of rutin. It can inhibit the aggregation of red blood cells and platelets, increase blood oxygen content, improve microcirculation, and promote the formation of new blood vessels. It is a good drug for treating occlusive cerebral blood vessels, protecting endothelial cells, and treating acute ischemic brain injury; It also has the effects of anti-radiation damage, anti-inflammation, anti-allergy, and anti-ulcer. It is the main component of Vinaluton and is often made into tablets and injections.
Troxerutin can inhibit platelet aggregation and prevent thrombosis. At the same time, it can resist vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability.

Sophora Flower, is a wide range of flowers and buds of the bean plants, but generally the open flowers are called "locust flowers", also known as "locust", and flower buds are called "locust rice". The locust flowers are shrinking and curled, and the petals are scattered. The entire calyx is bell, yellow -green, apex 5 light cracks; petals 5, yellow or yellow white, 1 piece is larger, nearly round, apex slightly concave, and the remaining 4 long circles. Storing 10, 9 of which are connected, the flowers are slender. The pistil is cylindrical and curved. Light. The qi is slightly bitter, the taste is slightly bitter.

Troxerutin powder is extracted from Sophora japonica and is a natural plant-derived ingredient. It is one of the derivatives of the flavonoid rutin. Troxerutin has better water solubility and better efficacy than rutin. Troxerutin has a strong absorption effect on blue light, and at the same time has a good antioxidant effect, which can reduce various damages of free radicals to the skin and achieve anti-blue light effects.

Troxerutin Safety - HaCaT Cytotoxicity HaCaT cells (4x104 cells) were seeded into 96-well plates and pre-incubated with indicated concentrations of troxerutin for 4, 8 and 12 hours. After pretreatment, HaCaT cells were exposed to 50 mJ/cm² and cell viability was measured by water-soluble tetrazolium salt (WST-1) assay. Results were presented in triplicates and expressed as mean ± SE of percentage of control optical density (OD). Asterisks indicate significant differences (*p<0.05) compared to HaCaT cells treated with UVB alone

When the concentration of troxerutin is <=20μM, it has extremely low cytotoxicity to cells.

1. Troxerutin scavenges free radicals and protects cells from damage induced by oxidative stress.

Studies have found that cells exposed to blue light produce reactive oxygen free radicals in mitochondria. These highly reactive oxygen free radicals can damage mitochondria and DNA. Troxerutin absorbs blue light, reduces the damage caused by blue light to cells, and achieves the effect of preventing blue light.

2. Troxerutin powder reduces the damage of blue light to the skin by absorbing blue light.

3. Troxerutin anti-blue light - reduces the damage of blue light to the skin by scavenging free radicals
Studies have found that after cells are exposed to blue light, reactive oxygen free radicals are produced in mitochondria. These highly reactive oxygen free radicals can
Damage mitochondria and DNA. Troxerutin reduces the generation of oxygen free radicals through its antioxidant effect and achieves the effect of preventing blue light.

The effect of troxerutin on scavenging oxygen free radicals. Comparison of the ability of troxerutin and VC to scavenge oxygen free radicals.

Troxerutin UV Protection - protects cells from UVB-mediated growth arrest

Troxerutin prevented UVB-mediated growth arrest in a dose-dependent manner.
Troxerutin (5 μM) effectively protects cells from UVB-mediated growth arrest. Notably, pretreatment with 5 μM troxerutin for 8 h increased cell viability by 20.27% compared with untreated HaCaT cells exposed to UVB.
Overall, pretreatment with troxerutin protected cells from UVB-mediated growth arrest.

Troxerutin protects against ultraviolet rays - changes the expression of miRNA in HaCaT cells under UVB

Troxerutin alters the miRNA expression profile in HaCaT cells exposed to UVB. As mentioned in the Introduction, miRNAs play a key role in the UVB response through specific binding to target genes.

We used a miRNA gene microarray containing 1,368 probes representing 1,205 human miRNAs. Total RNA labeled with Cy3, a green fluorescent dye, was extracted from HaCaT cells treated with or without troxerutin and then exposed to UVB radiation. Each Cy3-labeled sample was hybridized onto a miRNA microarray. Using analysis software (GeneSpringGX version 11.5; Agilent), we first normalized the data for each sample using global normalization.

In previous studies, troxerutin-induced DNA repair enhanced its protective effect against gamma rays. Troxerutin increases DNA repair activity in HaCaT cells.

Furthermore, using miRNA microarray analysis and bioinformatics tools, we identified trotriptin-induced miRNAs and discovered a link between trostatin-induced miRNAs, as well as anti-apoptotic, enhanced migration, and DNA repair effects. . In HaCaT cells exposed to UVB, troxerutin changed the expression of 68 miRNAs, which were up- or down-regulated ≥2-fold.

Troxerutin antioxidant-eliminates free radicals

The ability of troxerutin to eliminate free radicals was tested by UV spectrophotometer. Troxerutin has good scavenging ability for a variety of different free radicals, and it has a certain dose dependence. The elimination ability of troxerutin was tested by UV spectrophotometer. Free radical ability Troxerutin has good scavenging ability against a variety of different free radicals, and it is dose-dependent.

Troxerutin antioxidant-inhibits lipid peroxidation

Troxerutin antioxidant summary. Troxerutin scavenges superoxide, nitric oxide, and other model-stabilized free radicals, and it reacts with hydroxyl radicals, carbonate, and thiocyanate anions. Protects different cell types (epithelial cells, fibroblasts and lymphocytes) from peroxyl radical-induced apoptosis, necrosis and mitotic death.

It cleared intracellular basal and inducible ROS levels and also restored depleted intracellular GSH levels, suggesting that free radical scavenging ability may be responsible for the observed cytoprotective effects in different cell types.

Troxerutin repairs red blood cells and improves dark circles.

It can be used to inhibit the aggregation of red blood cells and platelets, prevent thrombosis, increase blood oxygen content and promote angiogenesis. It can also build capillary resistance and reduce capillary permeability, thereby preventing edema caused by increased capillary permeability, reducing red blood filaments and improving dark circles.

1. Apply to the field of pharmaceuticals; make medicines or capsules to promote human health and restore physical energy.

2. Apply to the field of health products. Promote human function and enhance human immunity.

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying Troxerutin powder etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

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