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Introduction Of Liquiritin-Natural Flavonoid Compound from Licorice Root
Liquiritin is a naturally occurring flavonoid compound primarily found in licorice (*Glycyrrhiza* spp.). Due to its antioxidant and other properties, Liquiritin is widely utilized in the fields of cosmetics and dietary supplements.
Product Features
1. Natural Origin: Extracted from licorice root, it is a naturally derived active flavonoid ingredient.
2. Standardized Composition: Content is standardized via HPLC analysis, ensuring product consistency and stability.
3. Formulation Compatibility: Suitable for use in water-based, emulsion-based, and powder-based systems.
4. Gentle: Naturally sourced and suitable for the development of skincare and nutritional supplement formulations.
| Product Name | Liquiritin |
| Appearance | White to off-white powder |
| Source | Licorice Root |
| Detection Method | HPLC |
| Main Category | Flavonoids |
| Application Fields | Cosmetics / Dietary Supplements |
What Are The Benefits?
Anti-inflammatory and anti-allergic effects
It has obvious anti-inflammatory and anti-allergic effects and can inhibit the occurrence of inflammatory reactions and allergic reactions. It regulates immune system function and reduces the release of inflammatory mediators, thereby relieving inflammation and allergic symptoms. Clinically, it is often used to treat bronchial asthma, eczema, allergic rhinitis, rheumatoid arthritis and other diseases.
Anti-ulcer effect
It is widely used in the treatment of gastric ulcer and duodenal ulcer. It can increase the defensive function of gastric mucosa, promote the repair and regeneration of gastric mucosa, and reduce the occurrence and expansion of ulcer lesions. Additionally, it can reduce the pain and discomfort caused by acid reflux.
antiviral effect
It has a certain inhibitory effect on a variety of viruses, especially viruses such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). It can inhibit the replication and proliferation of viruses and reduce the risk of viral infection. Clinically, it is often used to treat diseases such as hepatitis B and AIDS.
Liver protection
It can increase the activity of antioxidant enzymes, reduce free radical damage to liver cells, and protect the liver. It can also promote the regeneration and repair of liver cells and improve liver function. Clinically, it is often used to treat acute hepatitis, chronic liver disease, liver fibrosis and other diseases.
Regulate blood pressure
It can inhibit the activity of angiotensin-converting enzyme (ACE), thereby reducing the production of angiotensin II, dilating blood vessels and lowering blood pressure. It can also promote urinary sodium excretion, reduce water and sodium retention in the body, and lower blood pressure. Clinically, it is often used to treat diseases such as hypertension and heart disease.
Anti-oxidize effect
It has strong antioxidant effect, can neutralize free radicals, reduce cell response to oxidative stress, and prevent cell aging and damage. Clinically, it is often used to prevent and treat Alzheimer's disease, skin aging, cancer and other diseases.
Other functions
In addition, it also has various pharmacological activities such as antibacterial, promoting digestion, and anti-diabetic. It can inhibit the growth and proliferation of tumor cells, has a certain inhibitory effect on bacteria, viruses, fungi, etc., can promote gastrointestinal motility, digestion and absorption, lower blood sugar, and play a role in treating diabetes.
Application Directions
Food additive field:
Liquiritin is a natural sweetener that has a sweet taste similar to sugar, is very low in calories, and has less impact on blood sugar. Therefore, liquiritin is used as a food additive to sweeten food and improve its taste. It can be used in candies, biscuits, beverages, chewing gum and other foods to flavor and sweeten.
Field of Traditional Chinese Medicine:
In the field of traditional Chinese medicine, liquiritin is a commonly used traditional Chinese medicine ingredient and is widely used in many aspects of treatment. It is often used to treat respiratory diseases such as pneumonia and bronchitis, and can relieve symptoms such as coughs and sore throats. In addition, liquiritin is also used to treat digestive system diseases such as ulcers, indigestion, weak spleen and stomach. It also has heat-clearing, detoxifying, anti-viral and other effects, and is also used in the treatment of some infectious diseases.
Pharmaceutical preparation field:
It is one of the important ingredients in many pharmaceutical preparations. Due to its anti-inflammatory, anti-allergic, anti-viral and other effects, liquiritin is often used in the preparation of anti-infectious drugs, anti-allergic drugs, anti-inflammatory drugs and other drugs. For example, liquiritin is used as an auxiliary ingredient in some drugs for the treatment of viral infections such as hepatitis B and AIDS.
Cosmetics field:
As a natural herbal ingredient, it has antioxidant and anti-inflammatory effects, so it is widely used in the field of cosmetics. It improves skin's smoothness and elasticity, reducing the formation of wrinkles and dark spots, while having a calming and soothing effect on sensitive skin. It often appears in skin care products, facial masks, lotions, essences and other products.
Beverage field:
It is also often used in the beverage field. It can be used to make drinks such as licorice tea and licorice oral liquid, which can help relieve throat discomfort, clear away heat and detoxify, and improve breath. In addition, it is also used to make some health drinks, such as drinks that nourish the stomach and protect the liver.
Recommended Market Applications
·Skincare Brightening Products
·Anti-aging Formulations
·Botanical Cosmetics
·Plant-based Supplements
·Functional Herbal Products
Liquiritin: Recent Research Progress
Colorectal cancer (CRC) is a highly prevalent malignancy globally that presents significant challenges in treatment; existing therapeutic modalities still face certain limitations. As a traditional medicinal plant, *Glycyrrhiza uralensis* (licorice) has garnered considerable attention in recent years, with its primary flavonoid constituent-Liquiritin-recognized as possessing significant therapeutic potential.
A study published in *Phytomedicine* (IF 6.7, Q1) systematically evaluated the mechanisms of action of licorice extracts and their active components in the context of colorectal cancer. Utilizing High-Performance Liquid Chromatography (HPLC) analysis, the study identified seven major constituents within licorice, among which Liquiritin was singled out as the key active substance. The analysis revealed that Liquiritin likely targets multiple tumor-associated proteins-including TP53, STAT3, SRC, and PIK3CA-and primarily modulates signaling pathways such as MAPK, PI3K-Akt, and apoptosis.
Through molecular docking and dynamics simulations, Liquiritin demonstrated a stable binding affinity for the TP53 protein, maintaining the structural integrity of the resulting complex via multiple hydrogen bonds. *In vitro* cellular experiments demonstrated that Liquiritin significantly inhibited the proliferation of SW480 colorectal cancer cells; concurrently, it suppressed their clonogenic potential, migration, and invasion capabilities, while also inducing apoptosis. Mechanistically, Liquiritin was found to downregulate the expression of invasion-associated proteins, such as MMP-1, MMP-3, and MMP-9.
In *in vivo* animal studies, Liquiritin treatment significantly inhibited the growth of xenograft tumors in nude mice, evidenced by a marked reduction in both tumor volume and weight. Furthermore, histological examination of tumor tissues revealed structural disruption and areas of necrosis; notably, no significant changes in body weight or signs of toxicity were observed. The study suggests that Liquiritin exerts its effects by upregulating p53 activity and inhibiting the phosphorylation levels of the p38 MAPK signaling pathway, thereby modulating the proliferation and survival of tumor cells.
A comprehensive analysis of these findings suggests that Liquiritin likely exerts its multi-targeted anti-tumor effects by modulating the p53/p38 MAPK signaling axis. This provides a robust scientific foundation for the potential application of Liquiritin in the development of functional ingredients and plant-derived active therapeutics.
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