Betulin Powder

What is betulin?

Betulin powder is a lupine-type pentacyclic triterpenoid compound composed of 6 isoprenes. The molecular formula is C30H50O2, the relative molecular mass is 442.72, and the melting point is 252-253°C. Soluble in ethanol, ether, chloroform, benzene, slightly soluble in cold water, petroleum ether and other organic solvents. In 1788, Leuth first reported that birch bark contained this substance and isolated it.

Soluble in ethanol, ether, chloroform and benzene, slightly soluble in cold water, petroleum ether and other organic solvents. The plant source is birch bark extract. Betulin has anti-inflammatory, anti-viral, inhibiting protein dissolution in hair fiber, improving the luster of damaged hair, promoting hair growth and other activities. It can be used in food, cosmetics, pharmaceutical and other industries.

Natural products lupine-type pentacyclic triterpenes such as betulin and betulinic acid, and their derivatives have a broad spectrum of biological activities, including antibacterial, anti-HIV, anti-inflammatory, anti-retroviral, anti-malarial, anti-obesity, hepatotoxic, Protective and immunomodulatory properties. In addition, these compounds are antioxidants and can reduce oxidative stress. However, its low bioavailability, strong hydrophobicity, and insufficient intracellular accumulation limit its use as a potential therapeutic drug. Therefore, it is necessary to improve the pharmacokinetic properties of this class of compounds. Usually, the structural modification of the triterpene skeleton involves the three most reactive functional groups, including: the secondary hydroxyl group at C-3, the primary hydroxyl group (betulin) or carboxyl group (betulinic acid) at C-28, and the isopropenyl side chain. Modifications at the C-2 position of the betulin or betulinic acid backbone or on the triterpene ring are rare.

Multiple studies have shown that one of the most promising structural modifications is the introduction of one or two triphenylphosphine groups at the position of its parent structure, thereby effectively improving its biological activity.

Product Details Table

What are the benefits?

1. Inhibit the formation of melanin

Betulin can be used as a natural, safe and side-effect-free traditional Chinese medicine phytoestrogen. It inhibits melanin synthesis in A375 cells through the p38-MAPK signaling pathway, reduces skin hyperpigmentation, and improves the impact of chloasma on the patient's appearance. At the same time, it does not Affected by side effects, reduce the incidence of uterine cancer and breast cancer.

2. Lower blood lipids

Betulin has good pharmacological effects in anti-hyperlipidemia and can simultaneously reduce blood cholesterol and triacylglycerols. In addition, it can also inhibit the function of cholesterol regulatory element binding protein (SREBP), thereby affecting cholesterol metabolism. It can significantly reduce the levels of triglycerides, fatty acids and cholesterol in the blood, improve hyperlipidemia and insulin resistance in obese patients, and is effective for II The treatment effect of type 2 diabetes is obvious.

3. Hepatoprotective effect

Betulin has a certain therapeutic effect on rats with alcoholic fatty liver disease. It can significantly improve the fatty change and necrosis of liver tissue caused by alcohol, inhibit the damage to liver tissue caused by alcohol-induced lipid peroxidation, and has good effects on alcoholic liver disease. Injuries have a better therapeutic effect.

4. Anti-inflammatory and antioxidant activity

Both betulin and betulinic acid are mildly anti-inflammatory at higher concentrations, and their anti-inflammatory properties may depend on inhibition of protein kinase C without involving any neurogenic inflammatory mechanisms. Inflammation is closely related to many diseases, such as bacterial pneumonia, alcohol-induced lung injury, mammary gland inflammation, myocardial protection, mouse foot injury, etc. Betulin can reduce LPS-induced acute lung injury by inhibiting pro-inflammatory factors induced by LPS and Escherichia coli, reducing myeloperoxidase activity and bacterial load in lung tissue.

Studies have shown that betulin has a certain therapeutic effect on mice injured by radiation, and its mechanism may be related to scavenging free radicals from the body; in addition, betulin has a protective effect on myocardial damage induced by doxorubicin in rats, and its mechanism may be related to Betulin inhibits oxidative stress.

5. Anti-HIV

Betulin, the main component of birch bark, can be used to derive powerful anti-HIV drugs and can be used as medicinal resources. The three mushroom substances in white birch mainly include betulin, betulinic acid, lupeol, etc. Most of these three compounds and their derivatives have anti-tumor and anti-inflammatory biological activities, and have inhibitory effects on protease and reverse transcriptase. Their scope of action affects almost every aspect of the virus life cycle, but most of the compounds focus on Virus adsorption stage. Cell experiment data completed by researchers at MarcPharmaceuticals in the United States showed that a new derivative of betulin can inhibit HIV-1 replication without any toxic side effects on cell activity.

6. Protect hippocampal neurons

Betulin can improve the depressive behavior of chronic stress depression model rats and has a certain protective effect on hippocampal neurons. Betulin protects synapses by increasing the expression of PSD-95 and Synapsin-I in the hippocampus, reducing the damage to hippocampal neurons caused by oxidative stress, and improving the learning and memory abilities of APP/PS1 double-transgenic dementia model mice. It has an improving effect, enhances the long-term hippocampus, and protects the cognitive function of experimental animals.

7. Resist fatigue and hypoxia resistance

Betulin can significantly extend the weight-bearing swimming time of mice, reduce the area under the blood lactate curve before and after exercise, and increase liver glycogen content, but it does not show an obvious effect in reducing urea nitrogen content. At the same time, it can significantly prolong acute cerebral ischemia. Hypoxia time, prolong the survival time of sodium nitrite poisoning, but did not show obvious effect in prolonging the normal pressure hypoxia resistance time. But the overall results show that betulin has the function of relieving physical fatigue and improving hypoxia tolerance.

8. Improve cognitive function

Betulin was used to intervene in APP/PS1 double transgenic dementia model mice, and the mice were randomly divided into model group, drug high-dose group and low-dose group, and C57BL/6J healthy mice served as the control group. The results showed that betulin can improve the cognitive dysfunction of model mice; the electrophysiological detection of the long-term potentiation (LTP) amplitude of the AD model group was lower than that of the control group. After intervention treatment with betulin, the LTP amplitude of each group was lower than that of the control group. The value was higher than that in the AD model group; the neuronal apoptosis rate in the AD model group was significantly higher than that in the control group, and the apoptosis rate decreased after betulin intervention; the expression of PSD-95 and Synapsin-I in the hippocampus of the AD mouse model decreased, However, its expression increased after intervention with betulin. Betulin can also significantly improve the behavior of Alzheimer's model rats, improve learning and memory abilities and spatial cognition, and significantly reduce the effects of PEN-2 related genes and proteins in Alzheimer's model rats, but has no effect on APH-1 related genes. and protein had no significant effect. Due to its protective effect on hippocampal neurons, betulin also has certain antidepressant effects.

9. Anti-wrinkles

Betulin can also repair wrinkles by promoting cell proliferation, increasing Col synthesis and the expression of related proteases.

Application

Health care products industry: 

Liver protection, anti-oxidation, protection of hippocampal neurons

Food industry: 

There are studies on using it as a preservative in meat products.

Cosmetics industry: 

Betulin powder inhibitory effect on collagenase activity and skin cell proliferation shows that it has a strong anti-aging effect and can be used to condition the skin, smooth the skin and prevent chapped skin. It is also a good external penetration aid

Daily chemical industry: 

In hair products, birch brain can reduce the dissolution of protein in hair fiber, improve the luster of damaged hair, and promote hair growth

Cosmetic-related pharmacological study of betulin

Company introduction and certificates obtained

YTBIO mainly supplies herbal extracts, functional cosmetic raw materials, organic products, etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA etc. We always maintain the highest requirements for product quality.

Our packaging

Our packing method is 1KG/Aluminium bags, 25kg/drum

For some products that require special packaging during transportation, we will carry out more delicate packaging. For example, retinal needs to be stored at -20 °C, so we choose cold chain transportation during transportation; deoxyarbutin will change color during transportation, so we will Vacuum packing of deoxyarbutin

Our team

Our team is professional, and our business team has undergone strict and professional product training. To ensure that our customers have a good cooperation experience and all questions during the cooperation process can be answered in a timely manner.

Factory

Payment method

The payment methods we support are: T/T, VISA, XTransfer, Master Card, Western Union, Alibaba Payment, e-Checking, Online Bank Payment

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We support shipping by sea, air, DHL, FedEx, TNT, UPS, EMS, SF

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