Silk Fibroin Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of silk fibroin powder in China. With abundant experience, we warmly welcome you to wholesale bulk silk fibroin powder for sale here from our factory. Quality products and reasonable price are available.

Silk fibroin powder is a natural polymer fibrin extracted from silk, accounting for about 70% to 80% of silk, and contains 18 kinds of amino acids, glycine (Gly), alanine (Ala) and serine (Ser) about more than 80% of the total composition. Silk fibroin has good properties such as flexibility, sustained release, air permeability, moisture permeability and tensile strength. After processing, it can be obtained in different forms such as fiber, solution, powder, film, and gel.

Silk fibroin is a kind of powdery polymer silk fibroin protein obtained by selecting the silk fibroin after high pressure degumming, processing it by a special process, and then using physical methods to pulverize it. The molecular weight is approximately 250,000. Tasteless, odorless, slightly soluble in water, insoluble in alcohol ether.

The main crystal structures of silk fibroin are Silk I and Silk II. A small and unstable Silk III structure is also present in the regenerated silk fibroin solution at the air/water interface. Silk I includes helices and other non-β-sheet conformations, while Silk II structure mainly refers to antiparallel β-sheet conformations.

The factory supplies Hydrolyzed Silk Fibroin, Silk Fibroin Powder,with 10 years of experience, we are committed to the pursuit of product quality. We currently have tens of thousands of customers and have been recognized by most of them. We are committed to establishing long-term cooperation. Relationships are the ultimate goal because we strictly control product quality and offer favorable prices. In order to save time and cost in the cooperation process, we have set up two overseas warehouses in the Netherlands and the United States to support direct shipment from overseas warehouses.

Test Report

 

 

Skin care functions of silk fibroin

 

Silk fibroin is an excellent natural moisturizing factor. Its natural moisturizing function is beneficial to skin health and has a good sun protection effect. In addition, it has antioxidant and inhibitory effects on skin cancer. It can be used in skin care and beauty cosmetics. production material. Because silk fibroin can increase the water content of the skin's stratum corneum, promote collagen synthesis, enhance skin tension and elasticity, promote pigment decomposition, and even skin tone, regular use of silk fibroin beauty and skin care products can make the skin white, moist, and shiny. , rich in elasticity, and can significantly improve skin problems such as sallow, dull, dry lines and loose skin.

Four major advantages of silk fibroin

At present, the most commonly used and powerful moisturizing ingredient on the market is hyaluronic acid. Taking it as an example, although it has strong moisturizing function and certain anti-aging and anti-inflammatory effects, it is obviously inferior to silk fibroin. It has more functions. Not only does it have the same powerful moisturizing effect, silk fibroin can also effectively inhibit the formation of tyrosinase. The average anti-UVB ability is as high as 90%, and the anti-UVA ability is more than 50%, which means it is more powerful. Whitening effect and anti-UV effect. For most skin care products, there are very few ingredients that can be moisturizing, whitening, anti-wrinkle, sunscreen, and anti-inflammatory at the same time. Therefore, silk fibroin can be said to have thousands of functions in one. Competition in today's skin care product market is so fierce. In this case, it still has high application prospects.

1. Good comfort. Silk fibroin has a smooth surface and produces low friction on the human body, so it can better protect every inch of our skin from irritation.

2. Good water absorption and waterproof properties. Silk fibroin is rich in a variety of hydrophilic groups. It contains a large number of natural moisturizing factors, which can penetrate deep into the bottom layer of the skin and absorb or emit moisture in the air. In winter, it can keep the skin locked in moisture and prevent it from feeling dry, or even tight or chapped. In summer, it can dissipate heat and sweat in time to keep you cool.

3. Good gloss. Silk fibroin is a pure natural product extracted from silk, so fabrics woven from silk have a silky luster.

4. Good UV resistance. Silk fibroin contains tryptophan and quinine, which can absorb ultraviolet rays and have excellent anti-ultraviolet effects.

Moisturizing function: Silk fibroin has extremely strong skin affinity. When it forms a film on the skin surface, it can not only absorb moisture when the external humidity is high, but also release moisture when the external environment is dry, keeping our skin moisturizing. The best state of moisture content. When your skin barrier is damaged, you need a product that is natural, non-irritating and has good moisturizing properties to help you repair

your skin.

Anti-wrinkle function: Silk fibroin is called the "Queen of Fibers". Its fibrous protein can enhance skin elasticity, accelerate skin metabolism, and prevent the formation of wrinkles.

Anti-aging function: Collagen is the main reason for ensuring that the skin does not age, but once collagen is lost, it cannot be regenerated. The main amino acids of silk fibroin are very similar to collagen. At this time, it can accelerate cell metabolism, repair the stratum corneum, delay skin aging, and slow down aging.

Sun protection function: Tryptophan and quinine play their greatest role, greatly reducing the damage of ultraviolet rays to our skin. Not only can they prevent sun exposure, but long-term use can also delay aging caused by photoaging.

Whitening function: It can inhibit the formation of melanin in the skin. With less melanin and having sun protection function, your skin will naturally become whiter and more delicate.

Hair care function: After hydrolysis, it becomes silk fibroin peptide. Silk fibroin peptide has good film-forming properties and can give hair gloss and moisturizing feeling. Protect the hair from external chemical damage and heat damage, provide the hair with the nutrients it needs, moisturize the hair and provide the nutrients it needs.

(1) Mechanical properties of silk fibroin

The initial modulus of natural silk fiber is 5-12Gpa, the breaking strength is 500Mpa, and the tensile elongation at break is 19%. Compared with natural silk fibroin fiber, the mechanical properties of regenerated silk fibroin materials have declined. Some polymer substances, For example, polyethylene glycol, polycaprolactone, polyvinyl alcohol, etc., can be blended with silk fibroin to improve the mechanical properties of silk fibroin materials. In addition, adding micro/nano-level substances to regenerated silk fibroin materials can also prepare silk fibroin materials with enhanced mechanical properties.

(2) Biocompatibility of silk fibroin

Biocompatibility refers to various complex biological, physical and chemical reactions resulting from the interaction between materials and the human body. Biomaterials implanted into the human body must be non-toxic, non-allergenic, and must not have adverse reactions to tissues, blood and immune systems. Silk fibroin is a natural high-purity protein secreted and synthesized by endothelial cells on the inner wall of silkworm silk glands. Its final degradation product can be absorbed by the body, and its molecular weight can also be adjusted by modifying the components of silk protein to achieve It adapts to the requirements of the internal environment of different organisms and therefore has good biocompatibility. Recent evidence from preclinical in vivo studies and human clinical experience in various applications demonstrates that highly pure fibroin is biocompatible after successful impurity removal.

(3) Biodegradability of silk fibroin

When silk is used as suture, it is found that it generally loses most of its tensile strength within 1 year, and the transplanted site cannot be identified after 2 years. Since the definition of absorbable biomaterials in regulations is that it loses most of its strength within 60 days after implantation, silk sutures The thread is classified by the FDA as non-degradable. However, a large number of experiments have proven the degradability of silk fibroin. In one experiment, a 10% aqueous silk fibroin solution was prepared into a mulberry silk fibroin scaffold with a pore size of about 850-1000 μm and implanted into rats. It was found that it began to degrade after a few weeks. , almost completely disappeared after one year. It is generally believed that this process is mediated by macrophages, thus indicating that the silk fibroin material can not only be biodegraded, but also bioabsorbed.

Due to the changeable environment in the body, the degradation process of silk fibroin in the body is relatively complex and is affected by the quantity and shape of raw materials, the location of the implant, the stress around the tissue, and the biological environment. But this uncertainty also provides people with good opportunities to achieve different purposes by regulating the structure and properties of silk proteins.

(4) Rich controllability

Silk fibroin has different structures from coilless to Silk I, II, III, etc. These structures have different physical properties. They can transform into each other. Controlling the different structures produced by silk fibroin and the ratio between the structures can obtain various properties. s material.

A high molecular weight, water-soluble silk protein. Silk powder has excellent natural moisturizing and skin care functions, can prevent partial ultraviolet radiation, prevent and treat some skin diseases caused by various dryness and wetness. It has a super strong effect and is used to prevent the production of sunlight.

And it also has a unique oil-absorbing ability, so it is suitable for cosmetics for oily skin. Particle sizes from 5um to 100um are available in a variety of sizes.

(1) There are hydrophilic groups in the silk structure, which is an excellent natural humidity control factor. A very thin silk powder layer is attached to the surface of the skin, which can absorb or release water with changes in skin temperature and humidity. This has a certain preventive effect on the skin's prevention and treatment of various skin problems caused by moisture or dryness.

(2) Its crystalline structure can reflect part of ultraviolet rays, and the holes formed by its spiral structure can absorb part of ultraviolet rays, so the combination of silk powder and sunscreen agent in sunscreen products has better sunscreen effect.

(3) It has a unique ability to retain oil, so it is also very suitable for oily skin cosmetics.

(4) Its structural characteristics can help reduce reflected light. When used in mica powder-based cosmetics, it can reduce reflected light and make it naturally reveal realistic and soft colors. Compared with talc and titanium dioxide, Silk powder has excellent air permeability, and cosmetics containing silk powder feel smooth after use.

In 1993, it was recognized as a biological material by American Foods. Compared with other natural biopolymers, silk fibroin has excellent mechanical properties and good biocompatibility, biodegradability, and versatility in structure adjustment, so it has a promising development prospect. These favorable properties are due to its unique physicochemical properties.

The relative molecular weight of silk fibroin is relatively large, and the molecular structure and intermolecular interactions are very complex. Generally speaking, the silk fibroin molecular chain consists of three subunits, namely the heavy chain (H-chain), the light chain (L-chain) and the glycoprotein. P25 composition. The heavy and light chains are linked by disulfide bonds, and then bind to glycoprotein P25 by non-covalent interactions such as hydrophobic bonds.

The heavy chain (H chain) consists of 5236 amino acid residues with a molecular weight of 391kDa; the light chain (L chain) consists of 266 amino acid residues with a molecular weight of 28kDa: the P25 protein is similar in size to the light chain, about 25kDa. The ratio of heavy chain, light chain and P25 in silk fibroin is about 6:6:1.

Silk fibroin of Bombyx mori is composed of 18 amino acids, of which glycine (Gly, 43%), alanine (Ala, 30%) and serine (Ser, 12%) account for about 85%.

The main crystal structures of silk fibroin are Silk I and Silk II. A small and unstable Silk III structure was also present in the regenerated silk fibroin solution at the air/water interface. Silk I includes helical and other non-β-sheet conformations, while Silk II structures mainly refer to antiparallel β-sheet conformations.

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