Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of hydroxypinacolone retinoate in China. With abundant experience, we warmly welcome you to wholesale bulk hydroxypinacolone retinoate for sale here from our factory. Quality products and reasonable price are available.
Description
Hydroxypinacolone Retinoate(HPR) is a derivative of retinols, which can directly bind to cellular retinoic acid receptors (RARs), has the effect of regulating skin epidermis and stratum corneum metabolism, and has anti-aging properties , Reduce seborrhea, lighten the skin epidermis melanin function. In cosmetics, it can prevent skin aging, treat acne, and whiten spots. Colleagues who ensured the powerful effects of retinoic acid greatly reduced his irritation
A derivative of retinol, which has the function of regulating the metabolism of epidermis and stratum corneum, can resist aging, reduce seborrhea, dilute epidermal pigmentation, prevent skin aging, prevent acne, whiten and lighten spots, etc. While maintaining the efficacy of retinol, it reduces its irritation and is currently used for anti-aging and preventing acne recurrence.
It supports sample testing and third-party testing. It has its own factory and many years of production experience. It has advanced equipment and can guarantee product quality and delivery. You can visit the factory. There are good after-sales service and very preferential prices, and there will be different discounts according to different order quantities.
Benefits
Hydroxypinacolone Retinoate has the following characteristics:
1.Better stability
2.Lower irritation, milder and lower risk of adverse reactions
3.The combination of HPR and encapsulated retinol can improve the area of chloasma, which is safe and effective.
Properties of Hydroxypinacolone Retinoate
Side chain modification of retinoids, why do we need to carry out side chain modification? Because it can bring different characteristics. Retinol is good, but it is not stable enough and is also relatively irritating. These problems can be solved through side chain modification, such as retinyl palmitate, which is much milder. However, the problem caused by side chain modification is that the effectiveness will be affected due to the increase in conversion steps. This is the same for vitamin C, vitamin E and other ingredients.
Fortunately, there are many ways to modify side chains, and researchers can modify the structure in various ways, and then select those ingredients that are both mild and efficient. As far as retinol is concerned, I was lucky enough to find hydroxypinacolone retinoate (HPR). Its structure is shown in Figure 2. Simply put, it is retinoic acid + pinacol.
The effects of using pinacol modification are direct effect, small molecular weight, easier transdermal absorption, low irritation, and high stability. It can be said that it has obvious advantages over other types of retinoids.
A research summary by Ruth et al., included in the famous dermatology journal JID, used an in vitro human skin model to compare the anti-aging and irritation properties of various retinoids, including HPR, trans-retinoic acid, and retinoids. Alcohol, retinaldehyde, retinyl palmitate. It was found that at the same concentration, HPR has a stronger effect at the gene transcription level than retinol, retinaldehyde, and retinyl palmitate, and at a concentration of 10 times, the cytotoxicity is even lower, but at the transcription level Less effective than trans-retinoic acid. Compared with the untreated control, HPR significantly promoted the synthesis of procollagen. Histological examination showed that the highest dose of HPR had a stronger effect than trans-retinoic acid, but the induced inflammation (marked by IL-1α) was no greater than that of the latter. Stronger. Based on these results, it is believed that HPR is an alternative to retinoic acid for skin anti-aging, but has fewer skin side effects.
Vincenzo Bettoli and colleagues conducted a 12-month study to examine the ability of a formula containing HPR and retinol to prevent acne recurrence. The patients first took isotretinoin orally in the first stage of treatment until the condition was relieved. Then they entered the second stage and used one form of this formula every day for 12 months. It was found that 15.38% of the patients relapsed. The patients tolerated the formula well and there were no reports. Adverse reactions indicate that the formula containing HPR and retinol is safe, tolerable and effective.
Another clinical study conducted by S. Veraldi et al. also contained HPR and retinol in the formula, as well as papain. It was used on 98 acne patients for 12 consecutive weeks to evaluate the effect on acne. The skin lesions were reduced by an average of 40.8%, and only 15.3% of the patients experienced local discomfort. The study found that it contains HPR, retinol, and papain. Formulated to be safe and effective for acne care.
Product Usage
Application in cosmetics
Anti aging, wrinkle removing and skin texture improvement Whitening and lightening spots, reducing skin melanin Acne elimination and auxiliary treatment acne
Suggestions on Formula Application
1. It is suitable for essence, emulsion, cream and oil products.
2. It is suggested that the formula should be used with antioxidants and light stabilizers.
3. packing materials recommended dark shade and airtight container.
HPR advantage
One of the significant advantages hydroxypinacolone retinoate has over retinol and other vitamin A derivatives used in active ingredient cosmeceuticals today is that it does not require a conversion to retinoic acid. Once applied to the skin it can bind directly to the receptors allowing a cascade of events to take place which produce the antiaging effects, reduction in pigmentation marks and blemishes, improving the appearance of fine lines and wrinkles, reducing sebum production, minimising pores and improving skin texture. Furthermore, increased hydration and an improvement in the glow of the skin can also be expected.
Compared with other forms of vitamin A in other forms of vitamin A, the second significant advantage is component stability. Thermal stress test shows that maintaining stability and effectiveness in the skin up to 15 hours.
Applicable Products
Anti-aging products: Promote the synthesis of collagen in the dermis and prevent the collagen from degrading too fast. The improvement of fine lines can be observed within a week.
Whitening products: Inhibit tyrosinase, promote metabolism, and accelerate the disappearance of melanin. The literature shows that it is equally effective in treating acne when combined with VC.
Acne products: reduce acne, reduce oil secretion, and dilute the pigmentation left by acne.
Sunscreen products: inhibit the enhancement of MMP activity caused by ultraviolet rays, protect elastin and dermal collagen, and improve wrinkles and fine lines caused by UV irradiation.
Repair products: promote the synthesis of hyaluronic acid in the body, reduce the TEWL of the skin, promote the activity of keratinocytes, increase the thickness of the epidermis, and make the epidermis stronger.
Product use
Add in low temperature stage, recommended dosage: 0.5-5.0%. The optimal pH range of the system is 5.0-6.3. The finished product should be protected from direct sunlight (with opaque packaging). It is recommended to add ultraviolet absorbers to day care products.
Flow Chart
Product Information Table
Product Name | Hydroxypinacolone Retinoate |
Appearance | Yellow Powder |
CAS | 893412-73-2 |
MF | C26H38O3 |
MW | 398.57812 |
Content | 99% Active substance |
Test Report
ITEM | STANDARD | TEST RESULT |
Assay | ≥98.0% | 99.54% by HPLC |
Physical & Chemical | ||
Appearance | Yellow powder | Complies |
Odor | Characteristics | Complies |
Uv-vis Absorption | Consistent with the reference | 1.0% |
Partical Size | 95% pass 80 mesh | Complies |
Loss on Drying | ≤0.4% | 0.18% |
Ash | ≤0.3% | <0.06% |
Heavy Metal | ||
Total Heavy Metals | ≤10.0ppm | <10.0ppm |
Conclusion | Conform with specification | |
Storage | Store in cool and dry places. Keep away from strong light and heat. | |
Packing | By 1kg/Bag | |
Shelf Life | 24 months under the above condition,and in it's original package |
Company introduction and certificates obtained
Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014. It mainly supplies functional cosmetic raw materials such as Hydroxypinacolone Retinoate, as well as herbal extracts and organic products. It has its own factory, R&D and quality inspection team, and has the conditions for development, production and sales. quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. We pay attention to the quality control of products and services, and provide effective after-sales service. Guarantee product quality and provide timely technical support to ensure customer satisfaction and trust. Our products and services excel in reliability and stability. Provide customers with a stable supply chain and delivery cycle, and ensure product consistency and reliability to meet customer needs.
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