Ascorbyl Tetraisopalmitate

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of ascorbyl tetraisopalmitate in China. With abundant experience, we warmly welcome you to wholesale bulk ascorbyl tetraisopalmitate for sale here from our factory. Quality products and reasonable price are available.

Ascorbyl tetraisopalmitate(VC-IP) is a newer form of vitamin C, composed of vitamin C and isopalmitic acid. Its unique feature is its significantly faster skin penetration compared to other forms of vitamin C. In short, it functions similarly to other forms of vitamin C, but with superior effects, making it one of the most effective forms of vitamin C available. Composed of ascorbic acid and four isopalmitic acid groups, it is a stable compound. Compared to regular ascorbic acid, it is more easily absorbed by the skin and can penetrate deep into cells, thus providing more effective moisturizing, whitening, and antioxidant benefits. These benefits include reducing fine lines and wrinkles, improving skin elasticity and firmness, regulating the stratum corneum, fading age spots, sunspots, and melanin deposition, combating free radicals, preventing DNA damage and weakened immunity, and protecting the skin from UV rays and environmental stressors. Ascorbyl tetraisopalmitate has become a popular ingredient in cosmetics, skincare products, and beauty products, receiving widespread attention and application.

Product advantages

1. Excellent transdermal absorption;

2. Inhibit intracellular tyrosinase activity and melanin production;

3. Reduce cell/DNA damage caused by UV (anti-UV/anti-stress);

4. Prevent lipid peroxidation and skin aging (anti-oxidation);

5. Good solubility in common cosmetic oils;

6. SOD-like activity (antioxidant);

7. Collagen synthesis and collagen protection (anti-aging);

8. Stable to heat and oxidation.

1. Inhibition of Melanin Production

Ascorbyl Tetraisopalmitate inhibits melanin production by suppressing tyrosinase activity. Human melanoma cells (HM-3-KO) were cultured with VC-IP at concentrations ranging from 0% to 0.2% for 4 days. Cells were then collected using trypsin and centrifugation. After cell counting, melanin density was measured using a Pharmacia laser densitometer. Compared to the control group, melanin synthesis in the VC-IP group decreased from 72% to 12%.

2. Inhibition of Matrix Metalloproteinase (MMps) Activity

VC-IP significantly inhibited MMP activity and suppressed UV-induced collagenase elevation. NHDF cells cultured in serum-free medium at 50 μm for 48 hours were ultrafiltered, concentrated, and cultured on an SDS-polyacrylamide gel containing 0.2% gelatin under non-reducing conditions. The gels were then stained with Coomasie Brilliant Blue R250 and measured using a laser densitometer. When using VC-IP (20-50µm), the activities of MMP-2 and MMP-9, which degrade gelatin, were inhibited to 18%-23% and 10%-17%, respectively. In contrast, the MMP activities in the VC (20-50µm) group were 39%-46% and 42%-52%, respectively.

3. Promotion of Collagen Synthesis

UV-induced release of collagenase from infiltrating cells leads to accelerated enzymatic degradation. In this case, the rate of collagen degradation exceeds the rate of biosynthesis, resulting in a reduction in collagen. Human skin fibroblasts (NHDF) cells were treated with L-[2,3H]proline for 24 hours, followed by cell lysis and subsequent neutralization with NaOH. The obtained cell extracts were thoroughly hydrolyzed with *Clostridium perfringens* collagenase, treated with TCAtannin, and centrifuged to produce a supernatant. The precipitate consisted of collagen and non-collagen components, which were evaluated using an Aloka liquid scintillation counter LC-3600 sci. VC-IP increased collagen synthesis in human skin fibroblasts by 170%-195% within a concentration range of 20-50 μm, while VC increased collagen synthesis by 112%-127% within the same concentration range.

4. Thermal Stability Test

VC-IP was stored at a constant temperature of 40℃ or 60℃ for one month. No significant changes were observed in appearance or color. The weight of VC-IP measured at 200℃ and heated at a rate of 5℃/min for temperatures ranging from 30-500℃ remained unchanged. These results indicate that VC-IP possesses good thermal stability.

Ascorbyl Tetraisopalmitate is mainly used in the field of cosmetics, it has good anti-aging and skin-brightening effects in cosmetics

Acts as a powerful antioxidant and whitening agent with anti-acne and anti-aging properties. It is a potent oil-soluble vitamin C ester. Like other forms of vitamin C, it helps prevent cellular aging by inhibiting collagen cross-linking, protein oxidation, and lipid peroxidation. It also acts synergistically with the antioxidant vitamin E and exhibits excellent transdermal absorption and stability. Numerous studies have confirmed its skin lightening, photoprotective and moisturizing effects. It can be found in various skin care products such as anti-aging serums, eye treatments, skin lightening gels and lotions/creams.

Ascorbyl tetraisopalmitate is an oil-soluble vitamin C derivative with antioxidant, anti-aging and whitening properties. It has high stability and is not easy to be oxidized. The effect is similar to VC, and the absorption rate is 16.5 times that of water-soluble vitamin C.

Recommended dosage: 0.05%-1%.

Get Premium Ascorbyl Tetraisopalmitate for Your Products!

Telephone/WhatsApp：+8617782577059
Email：sales@sxytbio.com

Hot Tags: ascorbyl tetraisopalmitate, China ascorbyl tetraisopalmitate manufacturers, suppliers, factory