Sustained Release Pellets

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of sustained release pellets in China. With abundant experience, we warmly welcome you to wholesale bulk sustained release pellets for sale here from our factory. Quality products and reasonable price are available.

As a professional Sustained Release Pellets manufacturer with our own production facility, we specialize in developing and manufacturing high-quality pellets (0.5–1.0 mm spherical granules) for nutraceutical, functional food, and pharmaceutical applications. Our advanced formulation technologies-including pellets, lipid-based delivery systems, coated pellets, sustained-release granules, liposomes, and nanoemulsions-are designed to improve ingredient stability, control release profiles, enhance bioavailability, and reduce formulation costs. Whether you need custom pellet development or large-scale OEM/ODM manufacturing, our experienced R&D and production teams can provide tailored solutions to meet your product requirements.

Looking for a reliable pellet manufacturing partner? Contact us today for a customized formulation proposal and a competitive quotation.

 Pellets are a multi-unit oral dosage form; a single dose typically consists of dozens to hundreds of small spherical units. They can be formulated into various types, such as sustained-release, controlled-release, or enteric-coated pellets.

Matrix-type sustained-release preparations
Matrix-type sustained-release preparations consist of a matrix formed from one or more polymeric materials that carries the active pharmaceutical ingredient; this composite is then processed into various solid dosage forms. Depending on the matrix material used, these preparations can be further classified into hydrophilic gel matrix systems, insoluble matrix systems, and erodible matrix systems.

Pellet-based sustained-release preparations
Pellets are spherical or quasi-spherical dosage forms with diameters ranging from 0.5 to 1.5 mm. Sustained-release pellets are composed of a core, a drug layer, a sustained-release layer, and a protective layer; the functions of these components are illustrated in the accompanying figure. The excipients used in sustained-release pellets determine the drug release rate and the site of release; selecting appropriate excipients enables the production of pellets with uniform particle size, smooth surfaces, and stable release profiles. Variations in the type, quantity, and method of adding excipients allow for the creation of pellets with different performance characteristics. While there is extensive research on Traditional Chinese Medicine (TCM) pellets-focusing primarily on preparation methods, excipient selection, and *in vitro* release-there is relatively limited research on the relationship between the properties of TCM raw materials (such as viscosity, flowability, and hygroscopicity) and pellet-forming characteristics, as well as on the *in vivo* absorption profiles of these pellets. Strengthening research in these areas is essential to advance the development of TCM sustained-release pellet formulations.
Compared to conventional oral dosage forms, sustained-release pellets offer advantages such as excellent flowability, high bioavailability, and well-defined drug release characteristics, making them a subject of increasing interest among researchers.
Common sustained-release pellet products currently on the market include time-controlled sustained-release labetalol hydrochloride pellets, enteric-coated pantoprazole sodium pellets, and sustained/controlled-release TCM pellets.

Excellent Flowability & Uniform Filling

The smooth, spherical shape of pellets ensures excellent flow properties, allowing more accurate capsule filling without additional flow agents. This also makes pellets an ideal choice for complex or multi-ingredient formulations.

Flexible Formulation for Various Active Ingredients

Pellets can incorporate a wide range of vitamins, minerals, botanical extracts, probiotics, and other functional ingredients, providing greater flexibility for customized formulations.

Controlled & Sustained Release

Pellets can be engineered with different release profiles, including immediate release, sustained release, controlled release, and delayed release, helping optimize ingredient delivery and product performance.

Improved Bioavailability

The large surface area and uniform distribution in the gastrointestinal tract promote more consistent absorption, helping improve the bioavailability of active ingredients.

Enhanced Ingredient Stability

Advanced coating technologies help protect sensitive ingredients from moisture, oxygen, gastric acid, and interactions with other ingredients, extending product stability and shelf life.

Better Consumer Experience

Pellet technology can reduce gastrointestinal irritation, mask unpleasant tastes and odors, and provide a more comfortable consumption experience compared with conventional dosage forms.

Reliable Manufacturing Quality

Pellet coating processes offer excellent batch-to-batch consistency, making them suitable for high-quality OEM and ODM supplement manufacturing.

Pellet Types

We provide customized pellet technologies based on your formulation requirements.

By Release Profile

• Immediate Release Pellets
• Sustained Release Pellets
• Controlled Release Pellets

By Release Mechanism

• Matrix Pellets
• Membrane-Controlled Pellets

By Coating Technology

• Enteric Coated Pellets
• Water-Insoluble Coated Pellets

Custom Pellet Manufacturing Services

With our own manufacturing facility and experienced R&D team, we provide complete OEM/ODM pellet manufacturing services, including:

• Custom pellet formulation development
• Sustained & controlled release technologies
• Enteric coating solutions
• Ingredient stability enhancement
• Capsule filling and finished dosage manufacturing
• Flexible packaging and private label services

Whether you are developing a new nutraceutical product or upgrading an existing formulation, our team can deliver customized pellet solutions tailored to your brand and market requirements.

Extrusion-Spheronization Method
Nakahara first invented the extrusion-spheronization pelletization technique in 1964, while Reynolds, Conine, and others pioneered the comprehensive introduction and application of this method in the field of pharmaceutics. It is currently one of the most widely used techniques for pellet preparation. The basic steps involve adding a binder to the drug and excipient powders and mixing them thoroughly; extruding the mixture into cylindrical strands using an extruder; cutting and rolling these strands into uniform spherical pellets in a spheronizer; and finally, drying the product. The process can be summarized as mixing, wet massing, extrusion, spheronization, and drying.

Hot-Melt Extrusion Method
Hot-melt extrusion primarily involves three steps: hot-melt softening, shaping, and solidification. The required materials are fed into a barrel with zoned temperature control and propelled forward by a screw. After melting or softening in specific zones, the materials are uniformly mixed through the action of shear and mixing elements and finally extruded through a die at a controlled pressure, speed, and shape. During extrusion, the particle size of the multi-component materials decreases while they undergo spatial rearrangement and interpenetration, ultimately achieving mixing at the molecular level and transitioning from a multiphase state at the inlet to a single-phase state at the outlet. The extrudate is then placed in a spheronizer and spheronized under heated conditions to yield the pellets. The key difference between hot-melt extrusion and extrusion-spheronization is that the latter relies on a binder to ensure material plasticity, whereas the former relies on heat.

Congealing Granulation Method
Congealing granulation is a novel, simple process suitable for preparing matrix-type pellets. First, the carrier material is melted at a temperature 5–10°C above its melting point, and the drug is thoroughly mixed with the carrier to form a solution or suspension. This mixture is then sprayed through a nozzle into an inert liquid, where it solidifies to form pellets. This process consists of two stages: forming and solidification. The former operates at 25–100°C, involving heating and melting, while the latter operates at 0–40°C, involving cooling and solidification. Depending on the density difference between the molten mixture and the inert liquid, the melt can be injected into the inert liquid from either the top or the bottom, ensuring the pellets are sufficiently cooled as they sink or float. Pellets produced via this method exhibit good sphericity and a narrow particle size distribution.

Freeze-drying granulation method
A drug-containing solution, emulsion, or suspension is rapidly sprayed into liquid nitrogen at -160°C to induce immediate solidification; water or organic solvents are subsequently removed via freeze-drying to yield the final product. This method can be used to produce both immediate-release and sustained-release pellets. Excipients in immediate-release pellet formulations typically include fillers (such as lactose and mannitol) and binders (such as polyvinylpyrrolidone); sustained-release formulations require the addition of release-retarding materials in addition to fillers and binders. The advantages of the freeze-drying granulation method include its suitability for heat- and moisture-sensitive drugs, as well as the production of pellets that are uniform, spherical, and possess a porous structure.

For more information about Sustained Release Pellets or other products, please contact:

Email: sales@sxytbio.com
Tel/WhatsApp: +86 177 8257 7059

Hot Tags: sustained release pellets, China sustained release pellets manufacturers, suppliers, factory