Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of caffeic acid phenethyl ester in China. With abundant experience, we warmly welcome you to wholesale bulk caffeic acid phenethyl ester for sale here from our factory. Quality products and reasonable price are available.
What is Caffeic Acid Phenethyl Ester?
Caffeic acid phenethyl ester (CAPE) is one of the main active components of propolis, possessing antiviral and antioxidant properties. It has inhibitory effects on herpes viruses, adenoviruses, and influenza viruses. Various compounds in propolis, including CAPE, quercetin, isopentenyl esters, rhamnetin, galangin, glycosides, and polysaccharides, exhibit anticancer activity.
The structure of CAPE contains an o-dihydroxy (catechol) phenyl group, a common free radical-scavenging structure. The presence of two adjacent phenolic hydroxyl groups increases the electron density of the benzene ring, making it prone to auto-oxidation and coloration. The chemical composition of propolis varies by region, and the CAPE content differs accordingly. Chinese propolis has a relatively high CAPE content (15–25 mg/g), whereas Brazilian propolis does not contain CAPE.
In the laboratory, CAPE can be synthesized using caffeic acid and β-bromoethylbenzene as raw materials, with potassium phosphate as a catalyst, achieving a yield of 60%.
Chemical Structure of CAPE
Caffeic acid phenethyl ester (CAPE) contains an ortho-dihydroxy (catechol) phenyl group, a common structural feature for free radical scavenging. The two adjacent hydroxyl groups in this structure increase the electron density of the benzene ring, making it prone to auto-oxidation and coloration.
According to research by Bors et al., the ortho-dihydroxy benzene structure plays a crucial role in the antioxidant activity of flavonoid compounds. Additionally, the double bond at the 2',3' positions in the CAPE molecule is relatively reactive, further enhancing its antioxidant properties.
The phenethyl ester group in CAPE is also essential for its biological activity, as it improves CAPE's ability to cross cell membranes, thereby facilitating its physiological and pharmacological effects.
What are the benefits?
Antioxidant Activity
Caffeic acid phenethyl ester (CAPE) exhibits strong antioxidant activity due to the presence of its catechol group. Studies have shown that CAPE can completely block the production of reactive oxygen species (ROS) in neutrophils at low concentrations (10 μM) and inhibit the xanthine oxidase (XO) system.
The main antioxidant components in propolis include CAPE, caffeic acid, tannins, kaempferol, galangin, and cinnamyl caffeate. Propolis containing CAPE exhibits stronger antioxidant activity, and CAPE has been found to have superior antioxidant capacity compared to galangin.
According to Ozyurt et al., the antioxidant effects of propolis extracts are stronger than vitamin E, with CAPE being one of the key active components. CAPE exerts its antioxidant effects by scavenging ROS, inhibiting XO and nitric oxide synthase (NOS), and reducing the consumption of superoxide dismutase (SOD).
Immunomodulatory and Anti-Inflammatory Effects
CAPE exhibits significant anti-inflammatory properties and has been shown to be effective in both acute and chronic inflammation models, such as formalin-induced arthritis and carrageenan-induced edema.
Additionally, CAPE plays an immunomodulatory role by affecting immune organs like the thymus and spleen, reducing thymus weight, and decreasing T-cell count.
Cardiovascular Regulation
CAPE influences vascular function through a dual mechanism:
- At low concentrations, it stimulates nitric oxide (NO) release, promoting vasodilation.
- At high concentrations, it inhibits intracellular and extracellular calcium ion exchange, thereby regulating vascular function.
These effects suggest that CAPE has potential applications in the prevention of cardiovascular diseases and post-surgical complications.
Other Biological Activities
CAPE also exhibits a range of additional biological activities, including:
- Inhibition of HIV-1 activity
- Suppression of superoxide anion formation from β-mercaptoethanol auto-oxidation
- Inhibition of xanthine oxidase activity
- Anti-lipid peroxidation effects
These properties highlight the broad biomedical potential of CAPE in various therapeutic applications.
Company Introduction
Founded in 2014, YTBIO mainly supplies food additives such as Caffeic Acid Phenethyl Ester, herbal extracts, functional cosmetic raw materials, organic products, etc. All of our products are produced by ourselves. At present, our certificates include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, etc. All our products have been tested and we support third-party testing. We provide a variety of products, for any detailed information about the products, please click Sales@sxytbio.Com Contact us, we will have professional sales staff to give you detailed answers
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