Sclareol Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of sclareol powder in China. With abundant experience, we warmly welcome you to wholesale bulk sclareol powder for sale here from our factory. Quality products and reasonable price are available.

Sclareol is a valuable natural aromatic compound. It is a white crystalline powder extracted from the stems and leaves of Salvia sclare L. (also known as Southern Salvia or Rosette Sage), a plant of the Lamiaceae family. This bicyclic diterpenoid is renowned for its unique aromatic properties. With a melting point of 95-105°C, it exudes a subtle amber aroma (similar to ambergris). Its aroma is characterized by a sweet, balsamic accord, a delicate, long-lasting aroma, and a strong, diffused quality.

In the fragrance industry, sclareol is considered an ideal raw material for the synthesis of ambergris products. It is primarily used to prepare natural ambergris substitutes such as sclareolide and ambroxol. It is also used in small quantities in the formulation of high-end fragrances. Its exceptional aromatic properties can impart a vibrant, harmonious, and long-lasting fragrance. In addition to its use as a spice, sclareol has medicinal value in the medical field, such as antibacterial, anti-inflammatory, and choleretic properties. In the agricultural field, it can be used to prevent and control crop rust and powdery mildew, and has the functions of killing insects and regulating plant growth activity.

This process uses sclareol extract with an alcohol content of 42.6% as the raw material to produce high-purity sclareol (≥98.5%) through the following steps:

Raw Material Dissolution:
Take 30 kg of sclareol extract and add 300 kg of 60% ethanol solution. Stir thoroughly until completely dissolved.

Low-Temperature Crystallization:
The solution is transferred to a freezer and frozen at -18°C for 8 hours to promote crystallization.

Primary Filtration:
A double-layer filtration system consisting of sponge and filter paper is used to obtain a yellow, transparent filtrate.

Decolorization and Purification:
Add 1.5 kg of activated carbon to the filtrate. After continuous stirring for 1 hour, filter through a 120-mesh filter cloth to obtain a colorless, transparent solution.

Secondary Crystallization:
The filtrate is diluted to a 20% concentration and stirred for 24 hours to allow complete crystallization.

Finished Product Processing:
a) Collect the white crystals using a 120-mesh filter cloth
b) Centrifugal dehydration
c) Vacuum drying (600 mmHg, 60°C, 6 hours)
d) Pulverization and screening
e) Finished product packaging

This process ensures a final product with an alcohol content of ≥98.5% and excellent purity and crystalline morphology through precise control of freezing temperature, stirring time, and vacuum drying parameters.

1. Antioxidant and Photoprotective Effects
Sclareol has significant antioxidant properties. Its molecular structure effectively scavenges free radicals and reduces cellular damage caused by oxidative stress. Studies have shown that this ingredient can alleviate UV-induced skin inflammation and slow the progression of photoaging by protecting keratinocytes from ROS. In vitro studies have demonstrated its potential to repair UVB-induced skin barrier damage.

2. Anti-inflammatory and Skin Barrier Repair
By regulating the NF-κB signaling pathway, sclareol can significantly inhibit the expression of pro-inflammatory cytokines such as TNF-α and IL-6. Clinical observations have shown that preparations containing 0.5-1% sclareol can alleviate pruritus in patients with atopic dermatitis (with an efficacy rate of approximately 68%). Its anti-redness effect is comparable to 1% hydrocortisone, but without the hormonal side effects. The mechanism of action involves reducing mast cell degranulation and inhibiting histamine release.

3. Immunomodulatory Function
Animal studies have shown that sclareol can enhance macrophage phagocytic activity (by approximately 40%) by activating the TLR4/MyD88 pathway, while also modulating the Th1/Th2 immune balance. In a mouse influenza virus model, prophylactic administration increased survival by 35%, suggesting its potential as an immune adjuvant. However, the effective dose in humans still requires clinical trials to determine.

4. Broad-spectrum Antimicrobial Properties
In vitro antibacterial studies (using the agar diffusion method) showed the following:

• Against Gram-positive bacteria: Inhibits Staphylococcus aureus (MIC = 32 μg/mL)
• Against fungi: Inhibits Candida albicans growth (inhibition zone diameter 12.3 ± 0.5 mm)
• The inhibitory effect on Propionibacterium acnes was superior to that of salicylic acid (P < 0.05).

This property makes it suitable for development as an adjunctive treatment for acne, and when used in combination with antibiotics, it can reduce the incidence of bacterial resistance.

1. Skincare Product Development
As a functional active ingredient, sclareol powder has been widely used in high-end skincare formulations:

• Anti-aging products: At a 0.1-0.5% addition, it reduces collagen degradation by scavenging free radicals and inhibiting MMP-1 activity (in vitro testing shows a 42% reduction in collagen loss).
• Soothing and Repair Series: When used in combination with ceramides, it can reduce transepidermal water loss (TEWL) by up to 35%, making it suitable for post-laser care.
• Sunscreen Booster: Enhances the UVA protection of SPF products and synergizes with titanium dioxide to improve photostability.

2. Functional Health Products
In the dietary supplement sector, it has three main application areas:

• Immune Modulation: A daily dose of 50-100mg can increase NK cell activity (preclinical data show a 28% increase).
• Chronic Inflammation Management: For arthritis patients, combining it with curcumin can reduce CRP levels (19% reduction compared to monotherapy).
• Gut Health: Regulating intestinal flora balance can alleviate IBS symptoms by up to 61%.

3. Frontiers in Pharmaceutical R&D
Current Key Research Areas and Progress:

• Neuroprotection: A 33% reduction in Aβ protein aggregation has been demonstrated in an Alzheimer's disease model and has entered Phase I clinical trials.
• Novel Drug Delivery System: Nanoliposome encapsulation technology increases oral bioavailability to 68% (compared to 12% for the API).

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