Lithospermum Extract

1. Hypoglycemic effect Lithospermum leaf extract and Lithospermum polysaccharide (A, B, C) have obvious hypoglycemic effects.
2. Antibacterial effect Lithospermum extract has an inhibitory effect on Jingke 68-1 virus in vitro, and has an inhibitory effect on Staphylococcus aureus, Staphylococcus albus, Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi, Streptococcus A, and Streptococcus B. cocci have obvious antibacterial effects.
3. Effect on blood coagulation: Intraperitoneal injection of shikonin components (shikonin, acetylshikonin) does not affect blood coagulation time, but can prevent the anticoagulant effect of heparin.
4. Anti-tumor effect Lithospermum extract has a certain inhibitory effect on the late stage of DNA synthesis (G2 phase) of Hela cells.
5. Tumor inhibitory effect Shikonin has the effect of inhibiting proliferation, promoting apoptosis and inducing cell cycle arrest of human choriocarcinoma drug-resistant cell line (JAR/MTX) cultured in vitro. Experiments show that the concentration of shikonin increases with the dose and With the prolongation of the action time, the inhibition rate of the growth of drug-resistant choriocarcinoma cells also increases significantly.
6. Effect of shikonin on hormone secretion. Experiments on the effect of shikonin on the hypothalamic-pituitary-gonadal axis function of adolescent female rats showed that the serum hormone levels of the shikonin group were significantly lower than those of the negative control group, and had no significant difference compared with the positive control group. Looks different. It shows that shikonin has an inhibitory effect on the hypothalamic-pituitary-gonadal axis function of rat Chemicalbook.
7. Experimental studies on antiviral effects have found that levo-shikonin at 6.0-0.75mg/mL can inhibit the pathogenic effect of parainfluenza virus on chicken embryo cells; shikonin can inhibit the replication of multi-drug-resistant HIV strains; lithospermum The polysaccharide has the activity of inhibiting HPV-DNA in vitro and has obvious anti-human papillomavirus effect.
8. Anti-inflammatory and anti-allergic effects. Both the aqueous extract and the alcohol extract of Lithospermum sinensis have certain anti-inflammatory effects and can reduce ear swelling in mice caused by xylene; they also have inhibitory effects on specific allergic reactions and can inhibit rats. The release of histamine from peritoneal mast cells is dose-dependent.
9. Hepatoprotective effect: Comfrey Lithospermum extract has a protective effect on liver damage caused by D-galactosamine, and can significantly inhibit alanine aminotransferase (ALT) and aspartate in mice with liver damage caused by D-galactosamine. Acid aminotransferase (AST) and malondialdehyde (MDA) increased and superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) decreased.
10. Other petroleum ether and chloroform extracts of Lithospermum sinensis can not only significantly inhibit lard oxidation, effectively scavenge free radicals, have strong reducing ability, but also participate in redox reactions.