What is D-panthenol?

Panthenol, also known as provitamin B5, is a widely used B vitamin nutritional supplement. It is widely used in medicine, food, feed, cosmetics and other fields, and is widely used in dermatology, skin care and hair care cosmetics.

Vitamin B5 is an essential nutrient for the skin. When the body lacks pantothenic acid, it will cause skin nerve disorders, and the skin will become keratinized, rough, and peeling. In severe cases, skin ulcers will occur. Panthenol is a homologue of pantothenic acid. Panthenol is more easily absorbed by the body than pantothenic acid, and is quickly converted into pantothenic acid in the body to participate in the physiological functions of tissues.

Vitamin B5 is pantothenic acid. Its properties are unstable and easily affected by temperature and formula, causing its bioavailability to decrease. Therefore, its precursor, panthenol, is often used in cosmetic formulas. Panthenol exists in three forms: dextrorotary body (D-form), left-handed body (L-form) and mixed body (DL-form). Among them, dexpanthenol (D-panthenol) has a higher Biologically active, D-panthenol is mainly used in the cosmetics industry.

Panthenol is a colorless, transparent liquid with a certain viscosity and a slight special smell. Compared with vitamin B5 or pantothenic acid, panthenol is more stable in nature. Its molecular weight is only 205. It can effectively penetrate into the stratum corneum and quickly convert into vitamin B5. The latter is an essential part of the body's metabolism and is responsible for the synthesis of coenzyme A. important raw materials. Coenzyme A is a cofactor for various enzyme reaction pathways in the body. It participates in cellular energy metabolism and supplies energy for the body's life activities. In addition, it also participates in the metabolism of various key components in the skin, such as the synthesis of cholesterol, fatty acids and sphingolipids. wait.

Therefore, panthenol has been widely used in the pharmaceutical, food and cosmetics industries. In the food industry, panthenol can be used as a nutritional supplement and fortifier; the topical use of panthenol on the skin began in 1944 and has a history of more than 70 years. It mainly plays the role of moisturizing, soothing and repairing in cosmetics.

Panthenol can be divided into three types: mixed body (DL-type), dextrorotary body (D-type) and left-handed body (L-type). Among them, only dexpanthenol has biological activity. Panthenol is widely used in medicine, food, feed, cosmetics and other fields, and is also common in skin pharmaceuticals, skin care, and hair cosmetics. In cosmetics and skin care products, panthenol is mainly used as a moisturizer, antioxidant and skin conditioner.

molecular structure (2)

Product Details Table

Product Name	D-Panthenol	CAS NO.	81-13-0
Molecular Formula	C9H19NO4
M.W.	205.25 gm/mol
Appearance	Transparent viscous liquid
Specification	98-102%
Solubleness	Soluble in water, ethanol, methanol and propylene glycol, soluble in chloroform and ether, slightly soluble in glycerol, insoluble in vegetable oils, mineral oils and fats

What are the benefits?

Hydrates and improves barrier

Panthenol, because it has hygroscopic and water-retaining properties, promotes lipid synthesis and increases the fluidity of lipid molecules and keratin microfilaments, it can improve the rigid environment between stratum corneum cells and help maintain healthy skin. Barrier skin care benefits.

Studies have proven that ubiquinol interacts with lipid segments and protein residues in the outer layer of keratinocytes, maintaining/increasing molecular mobility to compensate for reduced hydration, and increasing the mobility of lipid molecules and keratin microfilaments to improve the stratum corneum. Rigid environment between cells.

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Using panthenol-containing products on healthy skin can effectively increase the moisture content of the stratum corneum, and there is a certain dose-effect relationship.

In addition, after surfactants destroy the skin barrier function, using panthenol-containing products can effectively reduce transepidermal water loss and improve the skin barrier function.

soothing

Panthenol's soothing effect mainly comes from two aspects.

On the one hand, ubiquinol protects against oxidative stress damage. Cells will produce reactive oxygen free radicals under the action of internal and external stress factors. When cells have insufficient scavenging capacity for free radicals, the accumulated free radicals will have adverse effects on skin health and aging. Panthenol at this time can reduce the production of reactive oxygen free radicals in skin cells, and at the same time upregulate the skin's own antioxidant mechanism, including inducing skin cells to express more antioxidant factors - heme oxygenase 1 (HO-1 ), thereby improving the skin's antioxidant capacity.

On the other hand, panthenol can reduce the inflammatory response of the skin, inhibit the release of inflammatory factors, thereby reducing the inflammatory response, and effectively improve a variety of sensitive skin symptoms, including dry skin, roughness, scales, itching, erythema, chapped, etc. .

Promote repair

Skin damage repair is a complex process, which mainly includes four stages: hemostasis, inflammation, proliferation and remodeling.

After micro-surgery, the skin will be damaged. The use of products containing panthenol can effectively promote the regeneration of the skin epidermis, promote the proliferation and differentiation of epidermal cells, and accelerate the repair of epidermal damage caused by laser. At the same time, filaggrin, an important marker of keratinocyte differentiation and barrier function, also increased significantly, indicating that ubiquinol has an excellent functional effect in promoting skin barrier repair.

Promote wound healing

According to relevant experimental data, panthenol can stimulate the growth of epithelial cells, accelerate the healing time of epidermal wounds, and help regenerate the skin epidermal barrier. In addition, there are reports in the literature that using ointment containing 5% panthenol can speed up the healing time of epidermal wounds by 30%. A new 2019 study shows that panthenol promotes wound healing faster than mineral oil, and it can also improve scarring.

hair care repair

Panthenol is widely used in shampoos and conditioners because of its ability to bind to the hair surface, allowing it to be deposited on the hair during our daily use of shampoo and conditioner, thus protecting the hair fiber. In addition, it has also been proven to repair damaged hair and reduce damage caused by over-combing, because it can penetrate into the hair to provide long-lasting moisture, improve hair shine, reduce split ends, and strengthen hair strands.

repair

The beneficial effect of panthenol on wound healing is to promote fibroblast proliferation and accelerate re-epithelialization, both processes are important for the healing of deep and superficial wounds.

Fibroblasts are the key to the dermis. Ubiquinol can significantly upregulate the expression of IL-6, IL-8 and other cytokines, thereby stimulating the proliferation of dermal fibroblasts; it can quickly reduce the relative diameter of lesions and significantly improve the degree of epithelial re-epithelialization. .

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Fight skin inflammation

Panthenol can inhibit the release of inflammatory factors, thereby reducing the inflammatory response and soothing skin sensitivity. Experimental studies have shown that after using capsaicin to stimulate keratinocytes, the release of inflammatory factors IL-6 and IL-8 was significantly increased. After using ubiquinol, the release of inflammatory factors IL-6 and IL-8 was effectively inhibited. , indicating that ubiquinol can inhibit the release of inflammatory factors.

Prevent hair loss and grow hair

TGF-β1 can stimulate hair follicles to enter the catagen phase; VEGF stimulates hair growth and increases hair follicle straightness by promoting the supply of nutrients to hair follicles, and promotes the transformation of hair from the resting phase to the anagen phase.

Ubiquinol significantly reduced the expression of transforming growth factor TGF-β1, up-regulated the expression of growth factor VEGF, and promoted hair growth.

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Application direction

Panthenol has a small molecular weight, so it can effectively penetrate into the stratum corneum, moisturize the stratum corneum on the surface of the skin, and play a strong moisturizing role. Improve skin roughness: Panthenol can effectively improve skin roughness and make the skin soft. In addition, D-panthenol can penetrate into the hair to improve hair luster, reduce hair splits, repair damaged hair, and continuously moisturize hair.

Panthenol has many main uses. It is often added to shampoos and conditioners to have a certain repair effect on our hair and improve hair quality. Such a substance is also added to some skin care products, which can have a certain moisturizing effect on the skin. In addition, it is also used in the food and medical industries. D-Panthenol is widely used in pharmaceuticals, food, skin care products and liquid Chinese medicine preparations. When it enters the human body, it can be converted into pantothenic acid, thereby producing coenzyme A, promoting the metabolism of body protein, fat, and glycogen, protecting skin and mucous membranes, improving hair gloss, and preventing the occurrence of diseases. D-Panthenol can prevent wrinkles, inflammation, exposure to wind and sun, and erosion, prevent hair loss, promote hair loss, keep hair moist, reduce hair splits, prevent breakage and breakage, and protect, repair, and repair hair. Medical efficacy.

In the food industry, as a nutritional supplement and fortifier, D-panthenol promotes the metabolism of protein, fat, and glycogen, maintains skin and mucous membranes, improves hair gloss, enhances immunity, and avoids the occurrence of diseases; In the daily chemical industry, the medical care effect on the skin is mainly manifested as a deeply penetrating moisturizer. D-panthenol can promote the growth and development of squamous epithelial cells, promote wound repair, and have anti-inflammatory effects.

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Test Report

ITEM	STANDARD	TEST RESULT
Content(C9H19NO4)	≥75.0%	75.5%
Physical & Chemical
Appearance	Colorless or yellow viscous liquid, Has a slight special smell.	Complies
Specific Rotation[α]_D²⁰	+29.0° - +31.5°	Complies
Loss on Drying	≤1.0%	0.6%
Residue on ignition	≤0.1%	Complies
Refrangibility[α]_D²⁰	1.495-1502	1.500
PH	/	10.4
Heavy Mmetal (Pb)	/	<0.001
Microbiological Test
Total Plate Count	≤1,000cfu/g	Complies
Mold and Yeast	≤100cfu/g	Complies
E.Coli	≤10cfu/g	Complies
Salmonella	Negative	Negative
Staphylococcus	Negative	Negative
Conclusion	Conform with USP 41
Storage	Store in cool and dry places. Keep away from strong light and heat
Packing	By 10kg / Barrel, inner by double plastic bag
Shelf Life	24 months under the above condition,and in it's original package

Company introduction and certificates obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

certificate

Our packaging

1KG/Aluminium bags , 25kg/barrel

Storage: Store in a cool, dry, clean place away from moisture and direct light.

We also have special packaging for special products, such as: retinal - cold chain transportation; deoxyarbutin - vacuum transportation

Packing & shipping

Our team

We have a professional R&D team and sales team, which not only ensure product quality, but also ensure a good cooperation experience for customers in the pre-sale, in-sale and after-sale processes. Our sales team has been trained in professional product knowledge, and can respond and solve every problem in cooperation in a timely manner

Team