Glycyrrhetinic Acid Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of glycyrrhetinic acid powder in China. With abundant experience, we warmly welcome you to wholesale bulk glycyrrhetinic acid powder for sale here from our factory. Quality products and reasonable price are available.

Glycyrrhetinic Acid Powder is a natural sweetener extracted from licorice. Its sweetness is 250 times that of sucrose.
Glycyrrhize Glabra L. is a common medicinal food. Licorice extract is widely used as a natural sweetener in candies and canned foods. The sweet taste of licorice comes from glycyrrhizic acid and glycyrrhetinic acid. The former is a type of triterpene saponin, accounting for about 4% to 5% of the dry weight of licorice root. Glycyrrhetinic acid is 50 times sweeter than sucrose. Glycyrrhetinic acid is formed by the release of glycyrrhetinic acid in water, which is 250 times sweeter than sucrose.
Licorice (Glycyrrhize glabra L.) is a common medicinal and edible food. Licorice extract is widely used in candies and canned foods as a natural sweetener.
The main pharmacologically active substance contained in licorice is glycyrrhizic acid and its salts. The structure of glycyrrhizic acid is a five-ring three-mushroom compound, which is hydrolyzed to produce glycyrrhetinic acid and two molecules of glucuronic acid. Glycyrrhizinate is also hydrolyzed in the body into components such as glycyrrhetinic acid and licorice flavonoids. There are different optical isomers of glycyrrhetinic acid structure. Glycyrrhizic acid and its salts (ammonium glycyrrhizinate, dipotassium glycyrrhizinate) have weak biological activity compared to glycyrrhetinic acid. Glycyrrhetinic acid is a white to light yellow powder, insoluble in water, but soluble in ethanol and ether.
Glycyrrhetinic acid drugs are hydrolyzed by gastric acid or decomposed by the liver into glycyrrhetinic acid in the human body, and then are partially generated by intestinal bacteria in the body to exert drug activity. The main function of glycyrrhetinic acid drugs is the effect of glycyrrhetinic acid, which has anti-inflammatory, antioxidant, and anti-allergic effects; it can effectively scavenge superoxide free radicals and hydroxyl free radicals, inhibit lipid peroxides, and can effectively reduce tyrosine Enzyme activity inhibits the production of melanin in the skin.

Anti-allergic and soothing effect
Glycyrrhetinic acid is similar in structure to hydrocortisone. A large number of clinical trials have confirmed that it has good anti-inflammatory effects. It can effectively inhibit the production of prostaglandin PGE2 in inflammatory tissues and antagonize inflammatory mediators such as histamine.
It can directly bind to phospholipase A2, the initiating enzyme of arachidonic acid metabolism pathway, and to lipoxygenase that acts on arachidonic acid to produce inflammatory mediators, and selectively hinders the phosphorylation of these enzymes. Inhibit its activation.

Antibacterial effect
Glycyrrhetinic Acid Powder has strong anti-inflammatory and antibacterial effects and can inhibit the permeability of capillaries. When used in lipstick, it can prevent the rupture of brittle lips. It is also commonly used to treat mucosal diseases and can be used in oral hygiene products to prevent dental caries and mouth ulcers.

Auxiliary whitening effect
Glycyrrhetinic acid can inhibit the permeability of capillaries and has a good therapeutic effect on red blood cells and hormone dependence. It can effectively prevent stains caused by pigmentation caused by inflammation, eliminate micro-inflammation on the skin surface, and quickly improve skin quality. Brightens skin tone.

hormone-like effects
Glycyrrhetinic acid itself has a similar structure to steroid hormones, so it can exert glucocorticoid effects in the body.
It has the effect of activating hormone receptors and enhancing its own hormones or hormones administered through drug pathways, also known as glucocorticoid effect. Its structure is different from that of steroid hormones, so there are no adverse reactions and side effects of hormones.

Pharmacological effects
⒈Adrenocortical hormone-like effects
⑴Mineralocorticoid-like effects
For healthy people and various animals, glycyrrhetinic acid can promote sodium and water retention, increase potassium excretion, and exhibit deoxycorticosterone-like effects. When maintaining therapy with 40 mg hydrocortisone intramuscular injection daily for patients with bilateral adrenalectomy, if 4 g glycyrrhetinic acid daily subcutaneous injection is added, a synergistic effect will occur and the electrolyte balance will be maintained. However, if hydrocortisone is discontinued and only glycyrrhetinic acid is given, sodium storage capacity is lost and Addison's crisis occurs.
⑵Glucocorticoid-like effects
The chemical structure of glycyrrhetinic acid is similar to that of corticosteroids. For animals whose adrenal cortex has been removed and the pituitary gland removed, glycyrrhetinic acid can still produce sodium retention, antidiuretic and anti-inflammatory effects. Glycyrrhetinic acid 25 mg has a stronger effect on water and sodium retention in rats than deoxycorticosterone 1 mg. Therefore, it is believed that the deoxycorticosterone-like effect of glycyrrhetinic acid is not produced through endogenous deoxycorticosterone and aldosterone, but may be a direct effect. Some people also think that it is an indirect effect, that is, glycyrrhetinic acid inhibits the destruction of adrenal corticosteroids in the body, so the corticosteroid content in the blood increases accordingly, showing a more obvious adrenocortical hormone-like effect. Another report pointed out that glycyrrhetinic acid will only appear in people whose adrenal cortex function is weakened but not completely exhausted.
⒉Anti-inflammatory and anti-immune effects
Glycyrrhetinic acid has inhibitory effects on cotton ball granuloma, formaldehyde foot swelling, and subcutaneous granulomatous inflammation in rats. Its anti-inflammatory potency is about 1/10 of cortisone or hydrocortisone. Glycyrrhetinic acid can inhibit experimental arthritis in rats caused by carrageenan, and can inhibit allergic reactions in guinea pigs caused by horse serum or egg albumen to varying degrees. Its anti-inflammatory and anti-allergic responses may be related to inhibition of capillary permeability, antihistamines, or reduced cell responsiveness to stimuli.
⒊Effects on the digestive system
Glycyrrhetinic acid can reduce blood bilirubin and increase urinary bilirubin excretion in rabbits and rats with common bile duct ligation. This effect is stronger than glucuronolactone or methionine. It has good anti-ulcer effect on pylorus ligated rats. Its therapeutic index is high.
⒋Antitussive and phlegm-removing effect
The choline salt of glycyrrhetinic acid has a significant antitussive effect on coughs caused by chemical stimulation (inhalation of ammonia) and electrical stimulation of the superior laryngeal nerve in cats. Therefore, it is believed that its antitussive effect is related to the central nervous system.
5. Antidiuretic effect
Glycyrrhetinic Acid Powder and its salts have significant antidiuretic effects. It can enhance the reabsorption of sodium and chloride by the renal tubules and exhibit antidiuretic effect; its mode of action is different from that of deoxycorticosterone, which may be due to its direct effect on the renal tubules.
6. Impact on inner ear auditory function
Studies using auditory electrophysiology methods have shown that after intramuscular injection of 100 mg/kg glycyrrhetinic acid into guinea pigs, the action potential response threshold of the guinea pig's auditory nerve decreases, indicating that glycyrrhetinic acid has the effect of improving the auditory function of the inner ear of guinea pigs.
7. Inhibition of acetylcholinesterase
When glycyrrhetinic acid is used at a concentration of 4×10\-2mg/ml. It has a significant inhibitory effect on acetylcholinesterase, which is enhanced with the increase of drug concentration within this dose range. The drug concentration at 50% inhibition rate is 21.8±1.1mg/L. The inhibitory effect of glycyrrhetinic acid on acetylcholinesterase is a mixed competitive-non-competitive type, and has similar inhibitory effects to neostigmine.
8. Scavenging effect on oxygen free radicals
18-β-glycyrrhetinic acid 0.3mmol/L has a significant scavenging effect on oxygen free radicals released by human polymorphonuclear leukocytes (PMN), but has no effect on the oxygen consumption of PMN. 18-β Glycyrrhetinic acid has an obvious scavenging effect on O-2 and -OH produced in aqueous solution systems. 30mol/L has a significant inhibitory effect on the chemiluminescence produced by PMN. The results confirmed that 18-β glycyrrhetinic acid can directly capture oxygen free radicals.
9.Other functions
⑴Effects on estrogen
Glycyrrhetinic acid can inhibit the growth effect of estrogen on the uterus of immature animals, and it still has the same effect after the adrenal glands or ovaries are removed.
⑵ Antibacterial and antiviral effects
Glycyrrhetinic acid can enhance the effectiveness of berberine in inhibiting Staphylococcus aureus in vitro, and can also neutralize the virulence of tetanus toxin.
⑶ Effect on the production of reactive oxygen species by neutrophils and the concentration of intracellular free Ca2+
Rat experiments show that: 18-β sodium glycyrrhetinate 0.8~12.7mmol/L can selectively inhibit the production of Neu (neutrophils) reactive oxygen species induced by A-23187 (calcium ionophore); 25.4~203mmol/L stimulates Neu generates reactive oxygen species and enhances the reactive oxygen species generating effect of f-MLP. 18-β sodium glycyrrhetinate 25.5~203 or 6.3~50.7mmol/L inhibits the increase in Neu(Ca2+) induced by A-23187 or f-MLP, and above 101.5mmol/L also increases Neu(Ca2+).
⑷Effects on hypoxia in mice
Sodium glycyrrhetinate ip, 14mg/kg, 21mg/kg can significantly prolong the survival time of mice under normal pressure and decompression conditions, and enhance the mice's resistance to tissue hypoxia and cervical ligation caused by potassium cyanide and sodium nitrite. Tolerance of cerebral circulation hypoxia caused by arteries.
⑸Effects on myocardial ischemia
It can significantly counteract the electrocardiographic changes of acute myocardial ischemia in rats caused by pituitaryin.

1.As a natural sweetener, it is widely used in candy and canned food.

2. It can be used as a raw material for medicine, has the functions of anti-inflammatory, anti-allergic and inhibiting bacterial reproduction. It can also be used as antibiotics to treat infections of Staphylococcus, Streptococcus, Escherichia coli, Helicobacter, etc.

3. It can be added to cosmetics and has anti-inflammatory ,skin whitening effects.

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