Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of l-5-methyltetrahydrofolate calcium in China. With abundant experience, we warmly welcome you to wholesale bulk l-5-methyltetrahydrofolate calcium for sale here from our factory. Quality products and reasonable price are available.
L-5-Methyltetrahydrofolate Calcium 95% Supplier
YTBIO offers 95% pure L-5-Methyltetrahydrofolate Calcium, a bioactive form of folic acid that can be directly absorbed and utilized by the body, unlike traditional folic acid. We provide high-quality nutritional ingredients to global customers through stable supply capabilities, rigorous quality control, and flexible customization support.
Product Certificate of Analysis
|
Item |
Specification |
Result |
|
Description |
White to light yellowish powder |
Conforms |
|
Identification |
||
|
A: IR |
The IR spectrum of the sample should correspond to that of the standard of calcium L-5-methyltetrahydrofolate |
Conforms |
|
B: Calcium test |
Addition of ammonium oxalate TS to the solution of this sample will form white colored precipitate |
Conforms |
|
B: HPLC |
The retention time if major peak in the sample chromatogram should correspond to that of the standard in the assay preparation |
Conforms |
|
Related Compounds |
||
|
4-Aminobenzoylglutamic acid |
≤0.5% |
0.06% |
|
4a-Hydroxy-5-methyltetrahydrofolic acid |
≤1.0% |
0.22% |
|
(6R)-Mefox |
≤1.0% |
0.08% |
|
(6S)-Mefox |
≤1.0% |
0.08% |
|
Tetrahydrofolic acid |
≤0.5% |
Not Detectable |
|
7,8-Dihydrofolic acid |
≤0.5% |
Not Detectable |
|
Folic acid |
≤0.5% |
Not Detectable |
|
5,10-Methylenetetrahydrofolic acid |
≤0.5% |
Not Detectable |
|
5-Methyltetrahydropteroic acid |
≤0.5% |
Not Detectable |
|
Dimethyltetrahydrofolic acid |
≤0.15% |
0.08% |
|
Total impurities |
≤2.5% |
0.71% |
|
Chloride |
≤0.5% |
Conforms |
|
Water (K-F) |
6.0~17.0% |
12.8% |
|
Calcium (On anhydrous basis) |
7.0~8.5% |
8.3% |
|
Assay (On anhydrous basis) |
95.0~102.0% |
98.8% |
|
D-5-Methyltetrahydrofolate |
≤1.0% |
0.34% |
|
Heavy Metals |
||
|
Boron |
≤50μg/g |
<5μg/g |
|
Platinum |
≤10μg/g |
<0.05μg/g |
|
Arsenic |
≤1.5μg/g |
<0.01μg/g |
|
Cadmium |
≤0.5μg/g |
<0.005μg/g |
|
Lead |
≤1.0μg/g |
<0.02μg/g |
|
Mercury |
≤1.5μg/g |
<0.005μg/g |
|
Residual Solvents |
||
|
Ethanol |
≤0.5% |
0.0013% |
|
Isopropanol |
≤0.5% |
Not Detectable |
|
Microbe. Test |
||
|
Total Aerobic Microbial Count |
Max 1000CFU/g |
<100CFU/g |
|
Yeast & Mold |
Max 100CFU/g |
<10CFU/g |
|
E.Coli |
Absence/g |
Not Detectable |
|
Salmonella |
Absence/g |
Not Detectable |
|
Staphylococcus Aureus |
Absence/g |
Not Detectable |
|
Pseudomonas Aeruginosa |
Absence/g |
Not Detectable |
|
Candida Albicans |
Absence/g |
Not Detectable |
|
Clostridia |
Absence/g |
Not Detectable |
What is L-5-Methyltetrahydrofolate calcium?
L-5-Methyltetrahydrofolate Calcium (L-5-MTHF Calcium) is one of the active forms of folic acid in the human body's metabolic processes; it is also known as active folic acid or 5-methyltetrahydrofolate calcium.
L-5-MTHF Calcium does not require complex metabolic transformation and can directly participate in relevant metabolic processes in the human body. It is widely used in nutritional supplements and maternal and infant nutrition products.
Health Benefits
Folic acid deficiency reduces the ability of cells to synthesize and repair DNA. Supplementation with folic acid may be a more beneficial approach to increase folic acid, reduce homocysteine levels, and support normal cell proliferation, endothelial function, cardiovascular disease, and nervous system function. Supplementation with 5-MTHF, especially during pregnancy, has been shown to reduce the risk of neural tube defects and recurrence.
1. Pregnancy Health
Active folic acid calcium is an excellent source for improving folic acid levels during pregnancy. Its metabolic pathway is shorter and more direct, bypassing the MTHFR enzyme activation step, resulting in a lower risk of unmetabolized folic acid accumulation. It is suitable for women trying to conceive and pregnant women with genetic polymorphisms or weak folic acid conversion abilities, providing a stable supply of active folic acid needed for embryonic development and reducing the risk of neural tube defects.
2. Cardiovascular Health
L-5-Methyltetrahydrofolate, as the active form of folic acid, can directly provide a methyl group to homocysteine, accelerating its metabolic clearance and reducing homocysteine accumulation in the body. It can also stabilize the nitric oxide synthase cofactor tetrahydrobiopterin BH4, improving endothelial diastolic function, inhibiting vascular inflammation and thrombosis, and reducing damage to cardiovascular and cerebrovascular and nerve tissues.
Mechanism of Action of Active Folic Acid
L-5-Methyltetrahydrofolate Calcium (L-5-MTHF) is the only active form of folic acid in the human body. As a key coenzyme, it drives the one-carbon methyl cycle, participating in cellular nucleic acid synthesis to support growth and development, and regulating homocysteine metabolism to maintain vascular and nervous system health.
A one-carbon unit is an active group containing only a single carbon atom (methyl, methylene, formyl, etc.). It cannot exist freely and relies on L-5-MTHF for transport to complete the one-carbon metabolic cycle, which is one of the basic metabolic pathways in cells. L-5-MTHF can provide a methyl group to homocysteine, which, under the catalysis of methionine synthase (with vitamin B12 as a coenzyme), converts homocysteine to methionine, preventing the accumulation of homocysteine in the body and thus avoiding damage.
Methionine further generates S-adenosylmethionine (SAM), which is widely involved in key physiological processes such as DNA methylation regulation, histone protein modification, neurotransmitter synthesis, cell membrane phospholipid production, hormone synthesis and detoxification metabolism, directly affecting cell proliferation, gene expression, neural homeostasis, and cardiovascular health. After SAM completes methyl transfer, it is converted into S-adenosyl homocysteine, which is then broken down into homocysteine, returning to the folate one-carbon cycle and continuously maintaining systemic methylation balance.
The metabolic intermediate 5,10-methylenetetrahydrofolate can carry one-carbon units such as methylene and formyl groups, promoting the conversion of dUMP to dTMP, providing complete nucleotide raw materials for DNA and RNA synthesis. Nucleotides are the core basis of DNA replication, and sufficient active folate can ensure normal chromosome replication and maintain orderly cell division. During embryonic development, placental formation, hematopoiesis, and other stages of rapid cell proliferation, the body's need for folate increases significantly.
What are the advantages of active folic acid calcium?
1. Absorption Advantage
L-5-Methyltetrahydrofolate Calcium is the active form of folic acid in the human body. It can directly participate in one-carbon metabolism without enzymatic conversion, is not limited by genotype, and has a significantly higher bioavailability than traditional synthetic folic acid. It can also meet the daily nutritional needs of people with metabolic defects.
2. Safety Advantage
Ordinary synthetic folic acid requires enzymatic conversion for utilization. When enzyme activity is insufficient or large amounts of ordinary folic acid are ingested, some ordinary folic acid may enter the bloodstream before being fully converted, causing unmetabolized folic acid to accumulate in the body. This may reduce immune cell activity, mask early signs of vitamin B12 deficiency, and potentially lead to nerve damage.
Active folic acid calcium does not have conversion blockage issues and does not produce unmetabolized folic acid accumulation, making it safer and more effective for long-term supplementation in pregnant women and the elderly.
Recommended application product types
L-5-MTHF Calcium can be widely used in maternal and infant, cardiovascular, and emotional health dietary supplements and special dietary foods.
1. Pregnancy and Lactation Nutritional Supplements
L-5-MTHF Calcium is a commonly used folic acid source in high-end prenatal nutrition products.
2. Multivitamins
Suitable for multivitamin and mineral blends.
3. Women's Health
Can be used to develop products that meet women's nutritional needs.
contact us
YTBIO mainly supplies L-5-Methyltetrahydrofolate calcium etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.
Contact us now for samples, technical information, and customized quotes.
Telephone/WhatsApp：+8617782577059
Email：sales@sxytbio.com
Hot Tags: l-5-methyltetrahydrofolate calcium, China l-5-methyltetrahydrofolate calcium manufacturers, suppliers, factory
