Ziziphus Seed Extract

1. Sedative and hypnotic effects Total flavonoids and total saponins in Ziziphus jujuba seed can inhibit spontaneous activity of mice and synergize with sodium pentobarbital to induce sedation and hypnosis. They have sedative and hypnotic effects on rats, mice and cats.
2. Anticonvulsant effects The effects of Ziziphus jujuba seed alkaloids on the convulsion latency, death time and mortality rate of mice with strychnine-induced convulsions were studied. It was found that the convulsion time and death time of mice given Ziziphus jujuba seed total alkaloids and cyclopeptide alkaloids were significantly prolonged, indicating that Ziziphus jujuba seed alkaloids have anticonvulsant effects.
3. Anxiolytic effects The alcohol extract of Ziziphus jujuba seed has obvious anxiolytic effects. It is preliminarily proved that the flavonoids and polysaccharides in Ziziphus jujuba seed soup are the material basis of its anxiolytic effects.
4. Antidepressant effects Low, medium and high doses of Ziziphus jujuba seed total alkaloids were administered to mice orally. It was found that all doses of total alkaloids could shorten the immobility time of mice in the tail suspension despair model, and the false positive antidepressant effect caused by enhancing the autonomous activity of mice was excluded by empty field experiment.
5. Anti-stress ulcer effect Stress ulcer formation is related to central nervous system dysfunction. Chinese jujube seed can balance the process of central excitation and inhibition and improve stress ulcer.
6. Anti-arrhythmic effect Chinese jujube seed water extract has an antagonistic effect on arrhythmias induced by aconitine, chloroform, etc., especially for arrhythmias caused by aconitine. It has both preventive and therapeutic effects.
7. Preventing and treating arteriosclerosis, lowering blood lipids and lowering blood pressure Chinese jujube seed total saponins can significantly reduce the serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels in hyperlipidemic rats, increase the content of high-density lipoprotein cholesterol, and regulate the blood lipids of hyperlipidemic rats.
8. Analgesic effect Chinese jujube seed water extract can significantly reduce the convulsion rate and mortality rate. The mouse hot plate method experiment has a significant analgesic effect.
9. Effect on microcirculation Chinese jujube seed liquid can significantly dilate the diameter of microvessels.
10. Effect on anti-hypoxia ability Experiments have shown that it can significantly reduce the oxygen consumption of brain tissue.
11. Enhanced and anti-tumor effects The brown extract extracted from ethanol from Chinese date seeds can enhance the humoral and cellular immune functions of mice, and has a certain protective effect on mice with radiation damage. Chinese date seed oil has a certain inhibitory effect on the growth of solid tumors in S180 mice, and can significantly increase the spleen index and thymus index of S180 tumorigenic mice.

1. Calming and hypnotic

Ziziphus jujuba seed has a long history of being used for sedation and hypnosis. Modern experimental studies believe that the main flavonoids and saponin compounds that affect the central nervous system of Ziziphus jujuba seed are flavonoids and saponins. Ziziphus jujuba seed total saponins can reduce the spontaneous activity of mice, synergize the central inhibitory effect of sodium pentobarbital, significantly prolong the sleep time of mice at the threshold dose of sodium pentobarbital, and antagonize the central excitatory effect of amphetamine. Studies have also found that Ziziphus jujuba seed extract has an anti-anxiety effect at low doses and a calming effect at high doses.

2. Immune enhancement

Studies have found that Ziziphus jujuba seed extract can significantly increase the lymphocyte transformation value and antibody hemolysin of mice, as well as enhance the phagocytic function of mononuclear macrophages of mice; Ziziphus jujuba seed extract can enhance the humoral immunity and cellular immunity of mice, and can prolong the survival time of irradiated mice.

3. Cardiovascular health

The effects of Ziziphus jujuba seed on the cardiovascular system are mainly manifested in anti-myocardial ischemia and hypolipidemic effects. The active ingredients