Hesperidin Methylchalcone

Ellagic acid has a variety of biologically active functions, such as antioxidant function, anti-cancer, anti-mutation performance, and inhibition of human immunodeficiency virus. In addition, ellagic acid is also an effective coagulant, which has a good inhibitory effect on a variety of bacteria and viruses, can protect the wound from bacterial invasion, prevent infection, and inhibit ulcers. At the same time, studies have found that ellagic acid also has antihypertensive effects.
Antioxidant properties
1. Scavenging free radicals
Since the 1950s, the antioxidant properties of ellagic acid in vivo and in vitro have been continuously explored and studied, and more and more research results show that ellagic acid has strong free radical scavenging and antioxidant abilities. Ellagic acid has a scavenging effect on both oxygen free radicals and hydroxyl free radicals, and its ability to scavenge free radicals is higher than that of antioxidants such as sesamol, olive leaf extract and lutein.
2. Inhibition of lipid peroxidation

In terms of inhibiting lipid peroxidation, ellagic acid is considered to be the most effective inhibitor of the initiation stage of microsomal NADPH-dependent lipid peroxidation. Ellagic acid can also strongly inhibit lipid peroxidation induced by doxorubicin. Ellagic acid inhibits ferromyoglobin/hydrogen peroxide-dependent lipid peroxidation. Ellagic acid can prevent lipid peroxides (LPO) induced by exogenous substances in T cells, inhibit the generation of reactive oxygen species (ROS), and improve cell death caused by cytotoxins.

3. Other antioxidant activities

Ellagic acid can reduce cell damage caused by radiation, hydrogen peroxide and mitomycin C in mouse bone marrow cells. Ellagic acid effectively inhibits the oxidation of DCDHF induced by pernitrite and the oxidation of pernitrite itself. At the same time, ellagic acid prevents single-strand breaks induced by pernitrite in pTZ 18U plasmid DNA and nitration of tyrosyl groups in calf serum albumin. Therefore, in vitro, ellagic acid protects biomolecules from oxidation and nitration damage caused by pernitrite.

Other effects
Activation of pancreatic stellate cells is an important cause of pancreatic fibrosis, acute pancreatitis and other diseases. Ellagic acid inhibits the activity of activated protein-1 and mitogen-activated protein kinase induced by interleukin-1b (IL-1) and tumor necrosis factor-α (TNF-α), thereby inhibiting the transformation of newly formed pancreatic stellate cells into activated fibroblastic phenotypes. As a secondary metabolite, ellagic acid plays an anti-eosinophil activity role in the β-glucan peritonitis model. Ellagic acid is an effective inhibitor of eosinophils and can be used to treat allergic inflammation. Ellagic acid can resist carbon tetrachloride-induced liver poisoning in vivo and in vitro, and can also resist lipid peroxidation induced by tert-butyl hydroperoxide, so it has a protective effect on the liver.
Melanocytes are present in the basal layer of the epidermis, where melanin is produced. The raw material of melanin is tyrosine, which must be converted into DOPA and DOPAquinine by tyrosinase before melanin is formed. Ellagic acid inhibits the activity of tyrosinase to block the production of melanin.

Therefore, high-purity ellagic acid is mainly used as an additive in medicines, health foods and cosmetics as an antioxidant, human immunodeficiency virus inhibitor, skin whitening and other functional factors.