Fisetin

Fisetin, also known as fisetin or fisetin flavonoid, is a natural flavonoid compound widely used as an important raw material for high-molecular pharmaceuticals. It appears as yellow needle-like crystals and is mainly derived from plants of the Anacardiaceae family, such as *Castanopsis fargesii* and *Cotinus coggygria*, and is also widely found in common fruits and vegetables such as strawberries, apples, persimmons, tomatoes, and onions. This component has a melting point of approximately 348℃ and is readily soluble in organic solvents such as ethanol, acetone, and acetic acid, but almost insoluble in water, ether, benzene, chloroform, and petroleum ether, exhibiting significant polar selectivity in solubility.

In terms of pharmacological activity, fisetin exhibits a variety of well-defined biological effects. Studies have shown that it has a significant inhibitory effect on prostaglandin production in methylcholanthrene-induced transformed 3T3 mouse fibroblasts, with a half-maximal inhibitory concentration (ID50) of 42.0 μM. Simultaneously, fisetin can effectively inhibit total sugar reductase in the lens of the rat eye, with an IC50 of 10^-6 M, suggesting its regulatory potential in glucose metabolism-related pathways. In smooth muscle antispasmodic experiments, ursanthin exhibited a significant antagonistic effect against acetylcholine-induced small intestinal spasms in mice, with an efficacy approximately 166% that of papaverine, demonstrating potential antispasmodic physiological activity.

In high-end formulations and functional applications, high-purity ursanthin possesses the ability to synergize with ergothioneine, significantly enhancing the body's antioxidant defense system. Structurally optimized ursanthin derivatives show an efficiency 2.3 times that of the original product in scavenging senescent cells; while high-purity ursanthin formulations with a purity of 99.99% can effectively reduce the body's oxidative stress level by 59.9%, exhibiting excellent anti-aging and cell protection potential.

Currently, ursanthin liposomes prepared using the thin-film dispersion method have an average particle size of (60.32±1.08) nm, an encapsulation efficiency as high as (94.37±0.62)%, and a stable drug loading of (4.500±0.021)%. This formulation significantly improves the water solubility, in vitro release rate, and relative bioavailability of flavin, while maintaining good stability over 30 days. In vitro experiments have confirmed that this flavin liposome has a dose-dependent inhibitory effect on the proliferation of human hepatocellular carcinoma HepG2 cells. It also acts as a highly efficient cell scavenger, removing senescent cells and providing space for new cells, showing broad application prospects in anti-aging, anti-tumor, and cell repair fields.

Fisetin is a natural flavonol compound widely found in fruits and vegetables such as strawberries, apples, and onions. It possesses various potential health benefits, the main functions and effects of which are as follows:

1. Anti-aging and Cell Protection

Scavenging Senescent Cells: As a "senolytic scavenger," it selectively induces apoptosis in senescent cells, inhibits the senescence-associated secretory phenotype (SASP), reduces the accumulation of senescent cells in tissues, and delays tissue aging.

Extending Lifespan: In animal experiments, fisetin supplementation can extend the healthy lifespan and maximum lifespan of aged mice, with some studies showing an extension of up to 36%.

2. Antioxidant Effects

Directly scavenges free radicals (such as DPPH free radicals and hydroxyl free radicals), reducing oxidative damage.

Activates the endogenous antioxidant system, upregulates the activity of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), and enhances the cellular antioxidant capacity.

3. Anti-inflammatory effects

Blocks pro-inflammatory signaling pathways such as NF-κB and MAPK, reduces the expression of pro-inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), improves immune balance, and alleviates chronic inflammation.

4. Neuroprotective effects

Crosses the blood-brain barrier, inhibits β-amyloid protein deposition, enhances synaptic plasticity, improves cognitive function, and has potential therapeutic effects on neurodegenerative diseases such as Alzheimer's disease.

Reduces neuroinflammation and oxidative stress, protecting neurons from damage.

5. Metabolic regulatory effects

Activates the AMPK signaling pathway, improves insulin resistance, and helps control blood sugar and metabolic health.

Inhibits α-glucosidase, delays carbohydrate digestion and absorption, and helps stabilize blood sugar.

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

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