Procyanidin B2

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of procyanidin b2 in China. With abundant experience, we warmly welcome you to wholesale bulk procyanidin b2 for sale here from our factory. Quality products and reasonable price are available.

YTBIO provides high-purity Apple-Derived Procyanidin B2 (3%/95%/98%), which possesses excellent antioxidant activity and is widely used in dietary supplements, functional foods, and cosmetics. In addition to raw material supply, YTBIO also offers one-stop services to global clients, including OEM/ODM customization and formula development.

Product Features

• Naturally derived ingredients, aligning with clean label trends.
• Multiple specifications available: Offers 3%, 95%, and 98% purity products to meet diverse needs.
• HPLC testing: HPLC testing ensures stable ingredient content.
• Quality control: In-house factory with strict quality control, ensuring batch-to-batch consistency.
• Wide applications: Suitable for the food, dietary supplement, and cosmetic industries.

Procyanidin B2, chemically known as epicatechin-(4β-8)-epicatechin, is a type of proanthocyanidin (PC) widely found in various plants such as grape seeds, peanuts, apples, hawthorn, and tea.It exhibits high biological activity and stronger antioxidant capacity than vitamins C and E. Studies have shown that procyanidin B2 plays an important role in anti-inflammation, regulating blood lipids and blood sugar, and protecting the cardiovascular and nervous systems. Furthermore, procyanidin B2 (PB2) is also one of the most representative natural food colorings.

Natural Sources

PB2 is widely found in the flowers, fruits, leaves, and seeds of various edible plants, including those from the Rosaceae, Fabaceae, Nepeta, and Rhamnaceae families. Fruits of the Rosaceae family, such as hawthorn (Crataegus pinnatifida Bge.), apple (Malus pumila Mill.), European pear (Pyrus communis L.), peach (Prunus persica (L.) Batsch), and mugua (Chaenomeles Lindl.), are nutritious foods in people's daily diets and are also important sources of PB2. The concentration of PB2 in hawthorn fruit is as high as 243 mg/100g dry weight (DW), far exceeding that of catechins, coumaric acid, hyperoside, and isoquercitrin. Furthermore, PB2 has been found to be the second highest polyphenol content in traditional apple peel, at 954 ± 343 μg/g DW, and the highest among commercial apple varieties.

Proanthocyanidins B2 possess numerous biological activities, including anti-inflammatory effects, anti-obesity and anti-diabetic effects, anti-diabetic complications effects, liver protection, neuroprotection, gastrointestinal protection, vascular protection, kidney protection, and reproductive system protection. It also has the potential to treat/prevent various human diseases, such as diabetes, diabetic complications, atherosclerosis, and non-alcoholic fatty liver disease.

Antioxidant Effects

Proanthocyanidins B2 has extremely strong antioxidant capacity, effectively scavenging reactive oxygen species such as superoxide anion radicals and hydroxyl radicals, thereby delaying aging and preventing various chronic diseases.

Anti-tumor Effects

Recent studies have revealed the significant anti-tumor activity of proanthocyanidins B2, particularly in the treatment of liver cancer. These findings indicate that proanthocyanidins B2 has the potential to become a candidate anti-cancer drug.

Cardiovascular Disease Prevention

Proanthocyanidins B2 can lower cholesterol levels, protect vascular endothelial cells, inhibit low-density lipoprotein (LDL) oxidation, and prevent atherosclerosis and hypertension, playing a positive role in maintaining the normal function of the cardiovascular system.

Metabolic Regulation

Proanthocyanidins B2 can regulate lipid metabolism and also has certain neuroprotective effects.

Reference:Chen J, Zhong K, Jing Y, Liu S, Qin S, Peng F, Li D, Peng C. Procyanidin B2: A promising multi-functional food-derived pigment for human diseases. Food Chem. 2023 Sep 15;420:136101. doi: 10.1016/j.foodchem.2023.136101. Epub 2023 Apr 7. Erratum in: Food Chem. 2024 Feb 1;433:137359. doi: 10.1016/j.foodchem.2023.137359. PMID: 37059021. 

Researchers evaluated the efficacy and safety of topical proanthocyanidin B2 in treating male alopecia areata (AGA).

The study included 40 eligible male patients aged 18 to 50 years with AGA and Hamilton-Norwood classification II-V. Patients were randomly assigned to receive either topical proanthocyanidin B2 (n=20) or placebo (n=20) for 16 weeks. After treatment, patients returned for follow-up evaluation. The efficacy of topical proanthocyanidin B2 was evaluated using follicle microscopy and whole-body photography.

Results

Forty male patients with AGA II-IV (mean age 33.32 years, range 21-44 years) were included. There were no significant differences between the two groups in terms of age, duration of alopecia, and AGA classification (P > 0.05). At the end of the study, the topical proanthocyanidin B2 group showed a significant increase in total hair count compared to baseline compared to the placebo group (P < 0.05). Hair count during the growth phase was also significantly increased in the proanthocyanidin B2 group (P < 0.05).

This placebo-controlled study suggests that topical proanthocyanidin B2 is an effective and safe treatment option for patients with AGA.

Reference:Yeniay, Yıldıray & Arca, Ercan. (2022). Evaluation of the efficacy and safety of topical procyanidin b2 and placebo in the treatment of androgenetic alopecia in men; A randomized, double-blind, placebo-controlled study. Turkish Journal of Dermatology. 16. 108. 10.4103/tjd.tjd_41_22.

Food and Health Products

Used as a natural antioxidant in the development of functional foods and health products.

As a natural food coloring, it can be used as a safe food additive for coloring food and enhancing its health benefits.

Cosmetics and Personal Care

Used in hair growth serums, anti-hair loss shampoos, and other hair care products.

Commonly added to anti-aging, whitening, and antioxidant skincare products.

What Is The Difference Between Procyanidin B2 And Anthocyanins?

Procyanidin B2 belongs to the Proanthocyanidins family. Proanthocyanidins are generally multi-molecular polymers; anthocyanins are single molecules. In comparison, procyanidins have better stability and bioavailability.

Why choose apples as the source?

Apples are one of the important natural sources of Procyanidin B2, making them very suitable for the development of natural plant-based functional products.

Can it be used in cosmetics?

Yes. Procyanidin B2 can be used in antioxidant and anti-aging skincare product formulations.

Do you supply proanthocyanidins from other sources?

Yes, we also offer 95% proanthocyanidins from grape seed extract. Please feel free to contact us for more details.

YTBIO supplies high-quality apple proanthocyanidins B2 and offers flexible OEM/ODM solutions.Contact us now for samples, technical information, and customized quotes.

Telephone/WhatsApp：+8617782577059
Email：sales@sxytbio.com

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