Bisabolol: Product Overview
Bisabolol is a naturally occurring sesquiterpene alcohol compound. It exists in nature in both α- and β-forms, with α-bisabolol (especially the levorotatory isomer) being the most widely used due to its significant anti-inflammatory, soothing, and restorative effects. α-Bisabolol can be extracted from chamomile (Matricaria chamomilla) essential oil or synthesized. It is a colorless to pale yellow transparent oily liquid with a slight characteristic aroma.
YTBIO supplies α-bisabolol, a high-purity oily liquid with good batch stability. It is suitable for the development of creams, lotions, essential oils, and oral care products. It has complete certifications, supports customized packaging, and welcomes sample testing.
Sources and Preparation
1. Natural Sources
Bisabolol is mainly found in chamomile, sage oil, Candeia spp., and certain plants in the genera *Cephalotaxus* and *Salvia*.
2. Preparation Methods：
|
Process |
Raw Materials |
Characteristics |
|
Plant Extraction |
Chamomile, Brazilian Candeia tree |
High-purity single levo isomer, good safety profile |
|
Chemical Synthesis |
Farnesol, Limonene, Nerolidol |
High yield, low cost |
|
Biosynthesis |
Biomass such as corn (via genetically engineered microbial fermentation) |
Single (-)-α-bisabolol, low impurity content |
TEST REPORT:
|
Items |
Specification |
Results |
|
Content (C₁₅H₂₆O) |
≥95% |
99.81% |
|
Appearance |
Colorless liquid |
Conforms |
|
Identification |
The infrared spectrogram of the item should be consistent with reference substance of α-Bisabolol |
Consistent with infrared spectrogram of the reference substance |
|
Flavor & Odor |
characteristic |
Conforms |
|
Relative density |
0.924~0.930 |
0.924 |
|
Refraction index |
1.493~1.498 |
1.495 |
|
Specific Rotation |
-55 ~ -58° |
-55.3° |
|
Ignition residue |
≤0.1% |
Conforms |
|
Heavy Metal (Total) |
≤10ppm |
Conforms |
|
Arsenic (As) |
≤1ppm |
0.14PPM |
|
Mercury (Hg) |
≤0.1ppm |
0.005PPM |
|
Total Plate Count |
≤1000cfu/g |
≤200cfu/g |
|
Mold & Yeast |
≤100cfu/g |
≤30cfu/g |
|
Salmonella |
Negative |
Negative |
|
E. coli |
Negative |
Negative |
|
Conclusion |
Conform to the specification |
|
|
Storage |
Store in cool & dry place not freeze, keep away from strong light and heat |
|
|
Shelf life |
2 years when properly stored |
|
Core Efficacy and Mechanism of Action
1. Anti-inflammatory Effect: Bisabolol reduces the production of leukotrienes and prostaglandins by inhibiting the activity of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), thereby alleviating inflammatory responses such as redness, swelling, and pain. Natural bisabolol has a better anti-inflammatory effect.Experimental data show that after using 1% bisabolol products for 5 days, sunburn symptoms can be reduced by approximately 26%.
2. Soothing and Calming: Bisabolol can reduce skin erythema and edema caused by chemical irritation or UV radiation, and relieve stinging and itching.
3. Antioxidant: Bisabolol has strong natural antioxidant activity, capable of scavenging free radicals caused by UV radiation and environmental pollution, thus delaying skin aging.
4. Antibacterial Effect: It has an inhibitory effect on various skin pathogens such as Staphylococcus aureus and Propionibacterium acnes.
5. Skin Repair and Barrier Enhancement: It activates keratinocyte proliferation, promotes skin barrier repair, maintains water-oil balance, and accelerates wound healing.
6. Melanin Inhibition: Studies have shown that α-bisabolol can inhibit α-MSH-induced melanin production, reduce cAMP production and CREB phosphorylation, thereby exerting a melanin-reducing effect and possessing certain whitening potential.
7. Skin Penetration: Bisabolol can effectively penetrate the stratum corneum of the skin to exert its effects at a deeper level.
How does it work?
1. Anti-inflammatory signaling pathways: Bisabolol inhibits the NF-κB and AP-1 signaling pathways, downregulates iNOS and COX-2 gene expression, reduces the release of inflammatory mediators, and regulates redness and inflammatory responses at their source.
2. Antioxidant mechanism: By neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS), it enhances the activity of superoxide dismutase (SOD) and catalase (CAT), reducing lipid peroxidation levels.
3. Antibacterial mechanism: It disrupts bacterial cell membrane integrity, inhibiting bacterial growth and reproduction.
Applications and recommended dosage
1. Cosmetics and Personal Care
Bisabolol is a popular soothing and anti-inflammatory ingredient in the cosmetics industry, widely used in sensitive skin repair products, sunscreens and after-sun repair products, baby care products, acne treatment products, and whitening products.
2. Oral Hygiene Products
Added to toothpaste and mouthwash, it can reduce plaque and gum sensitivity, inhibit bacteria, and freshen breath.
3.Safety
Low toxicity and safety: Oral LD₅₀ in rats > 20 mL/kg, extremely low oral toxicity.
Good compatibility: Minimal skin and eye irritation at recommended concentrations.
Non-sensitizing: Naturally derived bisabolol has low sensitizing potential.
Regulation: Certified as a safe cosmetic/food ingredient by multiple international organizations.
| Product Category | Recommended Usage Concentration(For reference only) |
|---|---|
| Shampoo Products | 0.1 – 1% |
| Eyeliner & Mascara | 0.1 – 0.3% |
| Lipstick / Lip Balm | 0.15 – 1% |
| Face & Neck Products | 0.1 – 1% |
| Body & Hand Care Products | 0.1 – 0.5% |
| Facial Mask | 0.1 – 0.5% |
Company Introduction And Certificates Obtained
Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.
Packaging
1KG/Aluminium bags , 25kg/barrel
Storage: Store in a cool, dry, clean place away from moisture and direct light.
We also have special packaging for special products, such as: retinal - cold chain transportation; deoxyarbutin - vacuum transportation
Our Team
We have a professional R&D team and sales team, which not only ensure product quality, but also ensure a good cooperation experience for customers in the pre-sale, in-sale and after-sale processes. Our sales team has been trained in professional product knowledge, and can respond and solve every problem in cooperation in a timely manner
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