Bee Venom Powder

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of bee venom powder in China. With abundant experience, we warmly welcome you to wholesale bulk bee venom powder for sale here from our factory. Quality products and reasonable price are available.

Bee Venom Powder is the main active ingredient of bee venom. Bee venom is a transparent venom with an aromatic smell secreted by the venom glands and accessory glands of worker bees. It is discharged from the stinger when it is invaded. Among the many components of bee venom, melittin has the highest content, accounting for about 50% of the dry weight of bee venom, and it has high biological activity. Melittin is a linear peptide composed of 26 amino acids with a relative molecular weight of 2849. The order of amino acids in the Chemicalbook is: Gly-Isoleucine-Gly-Pro-Val-Leucine-Lys-Val-Leucine-Su-Su-Gly-Leucine-Pro-Pro-Leucine-Isoleucine-Silk-Se-Isoleucine-Lys-Sperm-Lys-Sperm-Val-Val-Val. Melittin has high biological activity. Modern pharmacological studies have shown that it has multiple effects such as anti-inflammatory, analgesic, platelet aggregation inhibition, and anti-AIDS. Melittin can produce a strong killing effect on a variety of tumor cells through different mechanisms. It is a natural anti-tumor drug with great application prospects.

Antibacterial and antiviral effects
Melittin has an inhibitory effect on the growth and reproduction of more than 20 kinds of Gram-positive and Gram-negative bacteria, and can also enhance the antibacterial efficacy of sulfonamides and penicillins. Melittin destroys the bacterial cell membrane by binding to the membrane to achieve the purpose of lysis. Melittin and its six derivatives can change the function of HIV-infected T lymphocytes, inhibit HIV replication, and reduce the infectivity of the virus. Anti-tumor effect 1. Direct killing effect In vitro experiments have confirmed that melittin has a significant killing effect on various tumor cell lines such as osteosarcoma, ovarian cancer, and glioma, and the killing effect is positively correlated with the dose. Melittin can kill tumor cells and prevent the growth of tumor cells, and has no significant effect on the growth of normal cells. Melittin can insert into the cell membrane of K562 cells, form pores, promote Ca2+ influx, increase the Ca2+ concentration in the cell, cause cell lysis, and directly kill K562 cells. It is generally believed that bee venom peptide dissolves the cell mitochondrial membrane, resulting in the inhibition of the normal respiratory function of tumor cells, destroying their aerobic respiration ability, inhibiting the growth of tumor tissue, and directly killing tumor cells.
2. Immunomodulatory effect Cellular immunity is an important defense factor of the body against tumors and viral infections. The state of the body's cellular immune function plays an important role in the occurrence and development of tumors. Enhancing cellular immune function can play a certain anti-tumor effect.
3. Inducing tumor cell apoptosis Cellular apoptosis, also known as programmed cell death, is an active cell biological process controlled by multiple genes. Therefore, cell apoptosis is an active process, which involves the activation, expression and regulation of a series of genes. Modern research shows that many chemotherapy drugs can achieve therapeutic purposes by inducing cancer cell apoptosis, and whether to induce apoptosis has become one of the criteria for screening anticancer drugs. This information is edited and compiled by Shi Yan of Chemicalbook. (2015-09-18)
Treatment of rheumatoid arthritis
1. Inhibition of secretory phospholipase A2 (sPLA2) activity sPLA2 has a wide range of biological effects and plays an important role in infection, injury, inflammation and cancer changes. Melittin can inhibit the activity of sPLA2 from various sources, and the inhibition rate of sPLA2 activity in the synovial fluid of RA patients can reach 96%. Therefore, the application of melittin can alleviate the progression of RA.
2. Inhibition of membrane damage body (MAC) Subdose melittin can significantly reduce the rate of cell dissolution by complement. This protective mechanism may be related to melittin promoting Ca2+ influx, stimulating intracellular signal transduction system and protective protein synthesis. It suggests that the application of appropriate amount of melittin has certain clinical value in the treatment of RA. Studies in recent years have shown that different concentrations of melittin can affect cell function through different pathways and exert a variety of biological effects. The appropriate application of melittin will provide new treatment methods for certain diseases.

YTBIO mainly supplies Bee Venom Powder etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.

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