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What is Gymnema sylvestris extract Gymnemic acid?
Gymnema sylvestris extract Gymnemic acid is an extract of the root or tender branches and leaves of Gymnema sylvestre, a plant of the genus Gymnema in the family Apocynaceae, and contains compounds such as saponins and sterols. It has the effects of lowering blood sugar, lowering blood lipids, resisting tooth decay and inhibiting sweet taste reactions. Gymnema sylvestre extract can be made into weight-loss foods and beverages for preventing obesity and treating diabetes. It is safe to use and has reliable efficacy. It can also inhibit the formation of melanin and can be made into anti-freckle cosmetics.
Gymnema sylvestris extract Gymnemic acid is also known as Gymnema sylvestre, King Kong vine, Snake horn, and Rice spoon vine.
[Source] It is the root or tender branches and leaves of Gymnema sylvestre, a plant of the genus Gymnema in the family Apocynaceae. There are about 25 species of Gymnema sylvestre worldwide;
[Plant morphology] Woody vine, up to 4m long, with latex; the stem bark is gray-brown, with lenticels, and the young branches are finely hairy, gradually becoming hairless when old. The leaves are obovate or ovate-oblong, 3-8cm long and 1.5-4cm wide, with fine hairs only on the veins; there are 4-5 lateral veins on each side, arched and ascending; the petiole is 3-10mm long, with short soft hairs, and with clustered glands at the top. The cymes are umbrella-shaped, axillary, shorter than the leaves; the peduncle is 2-5mm long and with short soft hairs; the pedicel is 2-3mm long, slender, with short soft hairs; the flowers are small, greenish-white, about 2mm long and wide; the calyx lobes are oval, blunt-headed, and ciliated, and there are 5 glands at the base of the inner surface of the calyx; the corolla is greenish-white, bell-shaped, with oval lobes, blunt-headed, and slightly covered to the right; the corona is attached to the curved notch of the corolla lobes, and is thick and Hard stripes; stamens are born at the base of the corolla tube, anthers are oblong, with membranes at the top; pollinia are oblong and erect; stigma is wide and short conical, extending out of the anthers, follicles are ovate-lanceolate, 5-9cm long, about 2cm wide at the base, swollen at the base, gradually pointed at the top, hard exocarp, glabrous; seeds are ovate, thin and concave, truncated or obtuse at the top, rounded at the base, with thin edges, and the seed hairs in whorls at the top are white and silky; the seed hairs are about 3.5cm long. Flowering period is from May to September, and fruiting period is from October to January of the following year.
Pharmacological effects
1. Hypoglycemic effect Gymnemic acid can improve insulin sensitivity, promote insulin secretion, inhibit gluconeogenesis, thereby exerting a hypoglycemic effect. The total saponins of Gymnema sylvestris can significantly reduce the blood sugar level of diabetic rats, and the high-dose total saponins of Gymnema sylvestre (0.12g/kg) have the same hypoglycemic ability as Jiangtangling. No significant effects were found.
2. Lowering blood lipids and losing weight. Gymnema extract can interact with some glycolytic enzymes in the body, thereby lowering blood lipids. Total saponins can also exert weight loss effects by inhibiting food intake in high-fat rats. Gymnema extract can effectively reduce body weight, triglyceride and total cholesterol levels, atherogenic index, glucose levels and increase high-density lipoprotein levels in model rats. And it is believed that Gymnema extract can be used as a natural weight loss drug.
3. Inhibit sweet taste and anti-caries effect. Gymnema sylvestris extract has the effect of inhibiting sweet taste, and the active ingredient in gymnema gymnema leaves that inhibits sweet taste is gymnemenic acid. Gymnemite acid can cause hypogeusia and is good for There was no statistical difference in the inhibitory intensity of eight sweeteners including fructose, sucrose, stevioside, and xylitol, and the average inhibition rate was 77%. The peptide component in Gymnema sylvestris leaf extract can also inhibit the sweetness of sucrose, glucose, sugar gum and saccharin, but does not affect the taste of salty, sour and bitter. It is believed that the peptide can compete with those that control sweetness. The receptor protein binds and only inhibits sweetness without affecting other tastes. In addition, gymnemic acid can significantly inhibit the activity of glucosyltransferase, block the synthesis of extracellular water-insoluble glucan of Streptococcus mutans, inhibit the formation of dental plaque, and cause cariogenic bacteria to lose their cariogenic environment, thereby preventing caries. effect. Combination with glycyrrhizin can enhance the anti-caries effect and reduce the sweetness of glycyrrhizin.
4. Other pharmacological effects: Gymnema extract also has potential anti-malarial and anti-filariasis effects; it has a significant immunomodulatory effect on human neutrophils; gymnemic acid can prevent radioactive substances from damaging rat livers. Damage effect; significant activity against epithelial cells of breast cancer and lung cancer; inhibitory effect on microorganisms such as bacteria and fungi.
Company Introduction And Certificates Obtained
YTBIO mainly supplies Gymnema sylvestris extract Gymnemic acid etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.
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