Cinnamic Aldehyde

Cinnamic aldehyde is an aldehyde organic compound, a yellow viscous liquid, which exists in large quantities in plants such as cinnamon.

Cinnamic aldehyde naturally existing in nature is a trans structure. The molecule is a phenyl group connected to an acrolein, so it can be considered as an acrolein derivative. The color of cinnamaldehyde is caused by the π→π* transition, and the presence of the conjugated structure makes the absorption spectrum of cinnamaldehyde enter the visible light band. Cinnamaldehyde is commonly called cinnamaldehyde, which exists naturally in essential oils such as Sri Lankan cinnamon oil, cassia oil, patchouli oil, hyacinth oil and rose oil. Cinnamaldehyde has two isomers, cis and trans. The commercially available cinnamaldehyde, whether natural or synthetic, is a trans isomer.

one. Application of cinnamaldehyde in medicine

1. Sterilization, disinfection and antisepsis, especially effective against fungi. It is effective against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Staphylococcus albus, Shigella dysentery, A. typhi and paratyphi, Pneumococcus, Bacillus aerogenes, Proteus, Bacillus anthracis, Salmonella Enteritidis, Vibrio cholerae, etc. inhibitory effect. It has a significant bactericidal effect on Gram-positive bacteria and can be used to treat a variety of diseases caused by bacterial infections. The minimum inhibitory concentration (MIC) is 0.02-0.07ul/ml. For deep pathogenic fungi, the MIC is 0.1-0.3ul/ml. Research by Japanese medical experts has found that cinnamic aldehyde has significant effects on fungi. Research on the antifungal effects of cinnamaldehyde on 22 species of opportunistic fungi shows that cinnamic aldehyde is an active antifungal substance, mainly by destroying the fungal cell wall and making the drug more effective. Penetrates into fungal cells, destroys organelles and plays a bactericidal effect.

2. Anti-ulcer, strengthen stomach and intestinal motility. Its mechanism of action is due to the inhibition of ulcer active factors (gastric juice and pepsin) and the strengthening of defensive factors (gastric mucosal blood flow rate), as well as the inhibition of gastric mucosal potential reduction and mucosal protection. In addition, cinnamaldehyde can reduce pancreatic enzyme activity. Cinnamaldehyde is an aromatic stomachic and carminative agent that has a soothing and stimulating effect on the gastrointestinal tract. It can promote the secretion of saliva and gastric juice, enhance digestive function, relieve gastrointestinal smooth muscle spasm, and relieve intestinal spasmodic pain. It is used to treat stomach pain, flatulence and colic, and has significant stomach-strengthening and carminative effects.

3. Fat decomposition effect. Cinnamaldehyde inhibits the release of fatty acids by epinephrine and ACTH and promotes the fat synthesis of glucose. Cinnamic acid also has this effect, but the effect of cinnamaldehyde is much greater than that of cinnamic acid. Therefore, it can be used in blood sugar control drugs to enhance the ability of insulin to replace glucose and prevent and treat diabetes.

4. Antiviral effect. For influenza virus, the tumor suppressive effect caused by SV10 virus is powerful.

5. Anti-cancer effect. It can inhibit the occurrence of tumors, and has anti-mutagenic and anti-radiation effects.

6. Dilate blood vessels and reduce blood pressure. It has antihypertensive effect on adrenocortical hypertension.

7. Aphrodisiac effect. A study by the Chicago Treatment Research Center in the United States showed that cinnamic aldehyde has a certain effect on male impotence.

8. Commonly used in external medicines and synthetic medicines. It is used in massage lotions and beauty products to disperse blood congestion, promote blood circulation, warm the skin, and tighten skin tissue. External use in massage can make the limbs and body comfortable and improve water retention. It is effective in softening and removing skin scars and fibroids. It is also used in external medicines for bruises such as safflower oil, cooling oil, and Huoluo oil. It mainly activates muscles and bones and disperses blood congestion. It has the functions of sedation, analgesia, antipyretic, anticonvulsant, and regulation of the central nervous system. It can also increase white blood cells and Platelet count. It also has a strong fungicidal effect and has a suppressive effect on skin fungi. In short, cinnamaldehyde can not only be used as raw material medicine itself, but also added to various external medicines and finished medicines. It can also be further processed to synthesize many powerful medicines.

two. Applications of cinnamaldehyde in chemical industry

1. Organic chemical synthesis. Used to synthesize α-bromocinnamic aldehyde, cinnamic acid, cinnamyl alcohol, cinnamonitrile and other series of products.

2. In industry, it can also be made into color developers and experimental reagents.

3. Insecticides, mosquito repellents, refrigerator deodorants, preservatives, etc. It has a strong killing effect on Aedes mosquito larvae that transmit yellow fever, and it will become a new insecticide. Cinnamaldehyde is not only safe and environmentally friendly, but also smells great. It contains cinnamaldehyde's antimicrobial agent, which repels insects. It can be used directly in drainage pipes (sewers) or car special fragrances, air fresheners, oxygen generators, refrigerator deodorants, preservatives, etc.

4. Cinnamaldehyde can also be used as a bactericidal algaecide and acidifying corrosion inhibitor in petroleum mining, replacing traditional anticorrosive bactericides such as glutaraldehyde currently used. It can significantly increase oil production, improve oil quality, and reduce mining costs. It opens up an unprecedented broad space for the application of cinnamaldehyde. The application of cinnamaldehyde in Hebei Oilfield and Shengli Oilfield has made significant progress in this regard, and the application test in Daqing Oilfield is also in progress.

5. Because the application of cinnamic aldehyde is not affected by the pH value like sodium benzoate, it has strong sterilization and disinfection functions for acidic or alkaline substances, and can also be widely used for antisepsis, mildew and preservation. As the application field of cinnamaldehyde continues to expand, at the annual meeting of the Chemical Sensing Federation, Dr. Zolads and others from Wheeling Jesuit University in the United States reported their new findings; cinnamaldehyde can enhance brain power and help enhance human memory. The results of this research are very promising and will bring new development and leaps to the cinnamon series products.

6. Cinnamaldehyde chewing gum can sterilize and deodorize. According to reports, experts from the School of Dentistry at the University of Illinois at Chicago reported a latest research result. Naturally flavored chewing gum containing plant extracts such as cinnamaldehyde can kill bacteria in the mouth. , and thus reduce the occurrence of bad breath. Cinnamaldehyde is a commonly used vegetable flavoring oil. In the experiment, 15 subjects chewed three types of chewing gum, namely cinnamon flavor, other natural flavors and gum without any flavoring, each time for 20 minutes. Twenty minutes after the subjects stopped chewing, a comparative test was conducted on their saliva before and after they chewed the gum. Microbiological analysis found that cinnamon-flavored chewing gum reduced the concentration of anaerobic bacteria in saliva by 50%, and even eliminated anaerobic bacteria on the back of the tongue by 43%. These anaerobic bacteria break down putrefactive proteins to produce volatile sulfides, which lead to unpleasant bad breath. Chewing gum without any flavoring is basically unprepared to reduce oral bacteria. Research shows that chewing gum containing cinnamaldehyde and other active plant extracts can serve as functional health foods and that they can have a positive impact on oral hygiene in the short term. Cinnamaldehyde chewing gum can not only be used to cover up bad breath, it can actually remove the bacteria that cause bad breath. The latest bird repellent colloids respond to the needs of the scene and adopt active evacuation methods, and the products are constantly being introduced. The use of natural flavoring---cinnamic aldehyde as a bird repellent colloid emerged at the historic moment. The active ingredient for repelling birds is high in cinnamaldehyde and has a long effect. High-concentration products are used in airport waterways. The biological bird repellent colloid, which uses cinnamaldehyde as the main raw material, can slowly and persistently release a gas that affects the central nervous system of birds. The birds fly away immediately after smelling it and will not come back during their memory period. It not only effectively drives away birds, but also does not harm birds. It is a green and environmentally friendly bird repelling product that solves a world-class problem for mankind.

three. Application in flavors and fragrances

As a hydroxy acid aroma compound, cinnamic aldehyde has a good aroma-retaining effect and is used as a raw material in perfumery to make the aroma of the main spice more fragrant. Because it has a higher boiling point than other organic compounds with similar molecular structures, it is often used as a fixative. It is often used in soap flavors to prepare gardenia, jasmine, lily of the valley, rose and other flavors. It can be used in apple, cherry and fruit flavors in food spices.
Because cinnamic aldehyde can be used to prepare various flavors of fragrance, it can also have the dual effects of sterilizing and deodorizing the oral cavity. It is commonly used in oral care products such as toothpaste, chewing gum, and breath fresheners.

Four. Applications in the food industry Cinnamaldehyde in food

It is commonly used in edible spices, fresh-keeping, antiseptic and antifungal agents (paper). It is also a good seasoning oil to improve the taste and flavor. Such as: instant noodles, chewing gum, betel nut and other foods as well as baked goods such as bread, cakes and pastries.

Now the United States and Japan have researched and developed the application of cinnamic aldehyde in food additives, mainly to utilize its sterilization, disinfection, and antiseptic functions. As a food antifungal agent, cinnamaldehyde is non-toxic or low-toxic to the human body, and it can play a strong inhibitory effect on the reproduction of microorganisms. Soluble in ethanol, ether, chloroform, grease, etc. It has antibacterial effect. When the concentration is 2.5×10-4, it has a strong antibacterial effect on Aspergillus flavus, Aspergillus niger, Penicillium citrus, Fusarium moniliforme, Alternaria, Geotrichum candidum and yeast.

Cinnamaldehyde has a very good inhibitory effect on mold. Inhibits mold growth and has strong antibacterial effect. Can effectively kill bacteria, E. coli. Cinnamaldehyde is an antifungal active substance. Foreign researchers have studied the antifungal effects of cinnamic aldehyde on 22 species of opportunistic pathogenic fungi. The results showed that cinnamic aldehyde had antibacterial effects on all tested bacteria. In the study of the anti-aflatoxin effect and ultrastructure of cinnamaldehyde, it was found that cinnamic aldehyde has obvious anti-aflatoxin effect.

5. Application of cinnamaldehyde in feed

Cinnamaldehyde itself is a spice. It has the function of promoting growth, improving feed efficiency and controlling bacterial diarrhea in poultry and livestock. It can also increase the fragrance of feed, induce animals to eat, and prevent feed mildew for a long time. Adding cinnamaldehyde No need to add other preservatives later. Further research by experts found that cinnamic aldehyde also has the following properties.

1. Promote growth:

Cinnamaldehyde not only has good effects on pigs, but can also be used in chicken, duck, and cattle feed, which is of great help in shortening the time to market. What's more worth mentioning is that even high doses (25/50/100/200 ppm) will not harm the intestinal villi.

2. Improve feed efficiency:

Cinnamaldehyde is different from general growth promoters. It can actually increase the storage amount of nitrogen in the feed in the animal body (by about 7%). Nitrogen is the main component of the synthesis of animal muscle cells, so it has the potential to improve the quality of the carcass. Positive influence.

3. Tests show that cinnamic aldehyde has the effect of killing hemolytic Escherichia coli that causes diarrhea in pigs, but has no effect on harmless non-hemolytic Escherichia coli in the intestines. It is highly safe and has no concerns about reproductive disorders. Sows It can also be used safely in feed.

4. No residue issues:

Although cinnamaldehyde is absorbed into the diet, 90% of it is excreted in urine and 5% is excreted in feces 24 hours later. The remaining 5% is decomposed into nutrients after 24 hours of absorption and is found in meat. There are no residues harmful to human body.

In addition, tests on the soil mixed with feces from pig farms and chicken farms where cinnamaldehyde has been used for a long time found that 90 - 99% of the cinnamaldehyde has decomposed and disappeared after 24 hours of being excreted into the soil.

5. General usage and dosage:

Pig: 5-20 kg 100 ppm

20-60 kg 50 100 ppm

60-100 kg 50 ppm

Chicken: Chicken feed 40 ppm

Large chicken feed 20 ppm

Duck: 50 ppm

6. Application in health care and antisepsis

People in the industry generally believe that the world of Jinjiu is supported by cinnamic aldehyde! Jinjiu is made from Xiaoqu liquor as the base liquor and selected authentic medicinal materials. It has the health-care functions of anti-fatigue and immune regulation, and is also commonly known as "tonifying the kidneys and strengthening yang" among the people. Among the medicinal materials with aphrodisiac properties of Jinjiu, cinnamic aldehyde is the main medicinal material. It has good dilation of blood vessels, promotes blood circulation, and exciting effects. Compared with the Western aphrodisiac ingredient sildenafil (commonly known as "Viagra"), cinnamaldehyde has a milder effect and does not have any toxic side effects on the human body. It is known as It is China's plant-based "Viagra". The success of Jinjiu also lies in the fact that cinnamic aldehyde can cause people to have a harmless mental dependence. Once they drink it, they will never give it up for life, thus it has a large and loyal market. Dongjiu, a famous Chinese wine that has declined, will also choose the successful route of Jinjiu in its re-emergence strategy, using cinnamic aldehyde as the main medicinal material. The antiseptic effect of cinnamic aldehyde has also been strongly confirmed in areca nut processed products. In the streets and alleys of Xiangtan area in Hunan Province, betel nut can be sold in the open air without any packaging and does not deteriorate for a long time. The important reason is that the betel nut has been soaked in cinnamic aldehyde solution. As a preservative, cinnamaldehyde can not only greatly extend the shelf life, but also degrade into nutrients needed by the human body in the intestines, which is harmless and beneficial to the human body. Cinnamaldehyde can not only enhance the medicinal efficacy of areca nut and make betel nut purer, but its unique cinnamon aroma can also enhance the taste of betel nut.

A study by experts from the School of Dentistry at the University of Illinois at Chicago found that cinnamaldehyde can kill bacteria in the mouth and thus reduce the occurrence of bad breath. Microbiological analysis found that cinnamaldehyde reduced the concentration of anaerobic bacteria in saliva by 50%, and even eliminated 43% of anaerobic bacteria behind the tongue. The Wrigley series of chewing gums produced by Wrigley Sugar Co., Ltd. in the United States have this effect, and there are also toothpaste and oral cleaning manufacturers who will develop in this direction.

Cinnamaldehyde also has a huge potential market in the animal breeding market. The total amount of feed in my country exceeded 150 million tons in 2010. Cinnamaldehyde, as a non-nutritional functional feed additive, has the advantages of preventing feed mildew, promoting animal eating, improving feed conversion rate and meat production rate, and shortening the time to market. At the minimum addition of one thousandth, about 150,000 tons of cinnamaldehyde are needed throughout the year, and the market space is huge. PHYTOSYNTHESE in France, semi-feed, the largest feed producer in South Korea, Biomin Feed Additives in Austria, and feed production and breeding enterprises in Guangdong, Sichuan, Jiangsu, Shandong, Hebei and other places in China have used cinnamaldehyde as a non-nutritional functional feed additive.

Jiangsu Academy of Agricultural Sciences has invented a downy mildew fungicide pesticide that can promote crop growth. The fungicide includes 0.1-5% cinnamaldehyde, 10-30% emulsifier, 0.1-10% azone, 20-50% alcohol, and the rest is water according to weight percentage. When preparing the fungicide, cinnamaldehyde and azone are dissolved in alcohol and mixed evenly. The new fungicide has a good application in preventing and controlling crop downy mildew and promoting crop growth. The active ingredient of this botanical fungicide is derived from cinnamaldehyde, a plant extract with insecticidal and bactericidal functions. It also has multiple functions such as promoting crop growth and development, increasing production and income, improving quality, improving nutrient utilization, preventing and controlling pests, and being pollution-free. It is suitable for pollution-free, green and organic agricultural product production. The preparation has remarkable application effect, readily available raw materials, simple production process, great market potential, obvious economic and social benefits, and has a very broad application prospect.

YTBIO mainly supplies Cinnamic aldehyde etc. The company was established in 2014 and has many years of R&D and production experience. We are committed to the research and development, production and sales of raw materials for the 21st century health industry. The certificates obtained so far include ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA,etc. We always maintain the highest requirements for product quality.

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