Nicotinamide Mononucleotide

Shaanxi Yuantai Biological Technology Co., Ltd. is one of the most reliable manufacturers and suppliers of nicotinamide mononucleotide in China. With abundant experience, we warmly welcome you to wholesale bulk nicotinamide mononucleotide for sale here from our factory. Quality products and reasonable price are available.

NMN is a substance inherent in the human body and is also abundant in some fruits and vegetables. In the human body, NMN is the precursor of NAD+, and its function is reflected by NAD+. NAD+, also known as coenzyme I, stands for nicotinamide adenine dinucleotide. It exists in every cell and participates in thousands of reactions. NAD+ not only serves as a coenzyme, but also serves as a substrate for multiple signaling reactions in cells, participating in hundreds of reactions. Scientists from Washington University School of Medicine pointed out in a paper published in 2016 that after mice ingested drinking water with dissolved NMN, the concentration of NMN in the blood gradually increased within 10 minutes, and within 30 minutes, NMN circulated with the blood for many times. tissue, and synthesize NAD+ within the tissue, increasing NAD+ levels.

Nicotinamide mononucleotide is a synthetic substrate for coenzyme I, and NMN is also used in anti-aging research. Studies have shown that β-NMN can also regulate the secretion of insulin and also affect the expression level of mRNA. β-NMN has broad application prospects in the field of medical treatment. β-Nicotinamide mononucleotide is the product and key NAD+ intermediate of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction. It improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythms, in part through SIRT1 activation.

99% High-Purity NMN Raw Materials | Our Own Factory, Customizable, and Fully Certified

We have long specialized in the research and development and production of high-purity NMN raw materials, maintaining a consistently high purity of over 99%. We strictly adhere to international cGMP standards. As a factory with years of industry experience, we have established a comprehensive quality control system and equipped with advanced production and testing equipment to effectively ensure consistent product quality and on-time delivery.

We value deep trust with our customers, support sample testing and third-party inspections, and sincerely welcome you to visit our factory. Currently, our NMN raw materials are exported to numerous countries and regions, including North America, Europe, and Asia, and are widely used in pharmaceutical formulations, health foods, and functional nutritional supplements, earning continued recognition from numerous customers.

Leveraging the cost advantages of our own factory, we can offer competitive pricing and tiered discounts based on order volume. While maintaining competitive pricing, we prioritize building long-term, stable partnerships and provide comprehensive technical support and after-sales service. We also support OEM/ODM collaborations. Please feel free to contact us if you require samples or qualification documents.

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Improve brain function

As we age, our blood vessels become dysfunctional, causing a decrease in blood flow to the brain, leading to cognitive impairment.

NMN has been shown in animal experiments to improve cognition and reduce brain plaque and neurodegeneration in mice with Alzheimer's disease.

NMN can also delay the onset of stroke, prevent stroke damage, and improve cognitive function and mitochondrial health after stroke.

Cognitive impairment is sometimes linked to depression, and NMN has also been shown to alleviate depression in experiments on mice.

Restore blood vessel health

As we age, our blood vessels become stiffer and more susceptible to blockage. When blood vessels in the brain become clogged, a stroke may occur, leading to damage to brain tissue, heart attack, or stroke.

NMN restored blood vessel elasticity in mice by reducing senescent cells, preventing vascular aging, and reversing vascular dysfunction by reducing vascular inflammation, thereby alleviating hypertension.

Improve muscle function

Muscles are essential for our movement, stability, and strength. As we age, muscles lose their ability to regenerate and grow, muscle weakness makes us fatigue more easily, and our physical endurance decreases.

NMN appears to reverse these conditions, as one of its transporters has been shown to increase strength and physical endurance in mice.

In addition, NMN can also improve muscle strength and performance in older men, and improve oxygen utilization and exercise endurance in middle-aged runners.

Promote heart health

As we age, our hearts become more susceptible to problems such as irregular heartbeats, which can lead to serious consequences such as heart failure.

Research shows that NMN has the potential to prevent heart failure in mice. Heart tissue is a precious tissue that cannot be regenerated. When damaged, scarring (fibrosis) forms, resulting in decreased heart function. NMN helped repair heart function in mice by reducing scarring.

The continuous beating of the heart requires a large supply of energy, which depends on the health of the mitochondria. NMN can improve the metabolic process of the heart and prevent the occurrence of heart failure.

Prevent obesity and diabetes

Obesity is associated with a variety of metabolic problems, including insulin resistance and diabetes.

Mitochondria play an important role in energy metabolism, and NMN can increase the number of mitochondria in the livers of obese mice, prevent obesity, and help reduce fat. NMN also improves metabolism and health in mice born to obese mothers.

Overeating and obesity can seriously affect metabolism and lead to diabetes. Aging makes it worse.

Studies have found that NMN can reverse diet- and aging-induced diabetes and prevent diabetes-related kidney disease and neurodegeneration. In addition, NMN can improve muscle insulin sensitivity in older women.

Therefore, in addition to a healthy diet and exercise, NMN may help prevent obesity and diabetes.

Treats aging and damage to the eyes

Macular degeneration is an age-related eye disease that affects areas of the retina that degenerate and can lead to blindness.

Research shows that NMN can repair mitochondrial dysfunction associated with macular degeneration, helping to prevent or mitigate the disease.

As we age, our eyes are prone to dryness and inflammation. NMN can reduce inflammation and increase oil secretion, thereby treating dry eyes. In addition, NMN reduces cell death and wound size after eye injury.

These findings suggest that NMN has potential benefits for improving eye health.

Promote organ health

In addition to its anti-aging effects on the brain, vascular system, muscles, heart, metabolism and eyes, NMN has been shown to enhance the vitality of bone cells and promote bone formation in rodents.

It also reverses intestinal aging, prevents age-related kidney degeneration, and inhibits the development of liver fibrosis in rodents.

Therefore, NMN can also delay the aging of bones, intestines, kidneys and liver.

promote reproduction

NMN has also been shown to promote the recovery and improvement of reproductive function.

It can enhance the vitality of germ cells and improve the function of the reproductive system, thereby helping to improve reproductive capacity and increase fertility.

NMN has also been shown to have positive effects on fertility and reproductive health through experiments on rodents in studies.

Improve the function of DNA repair mechanism

As we age, DNA undergoes cumulative damage. Repairing DNA damage helps prevent age-related diseases. NAD+ provides energy to Sirtuins enzymes, which are guardians of health and play a key role in repairing DNA.

In addition, as cells divide, the DNA at the ends of chromosomes (telomeres) gradually becomes shorter. Telomere shortening can cause damage to genes and cells. Sirtuins slow this process by stabilizing telomere length.

Scientists work to enhance NAD+ to enhance the activity of Sirtuins. Research shows that feeding NMN to mice activates Sirtuins and repairs DNA damage caused by radiation and aging. In addition, NMN increases telomere length in mice and humans.

NMN significantly improves running endurance in aged mice

Research institutions such as Harvard University and the University of Washington have found that supplementing NMN or enhancing its synthesis can extend the lifespan and promote health in rodents.

Experiments show that after injecting NMN into mice, their running endurance almost doubled

In addition, the study found that increasing NMN synthesis more than doubled the lifespan of mice.

Injecting mice with an enzyme that drives NMN synthesis more than doubled the remaining lifespan of female mice.

Improve skin condition

NMN wakes up and repairs damaged skin cells, improves cell regeneration ability; enhances the self-regulation ability of the endocrine system, repairs the skin's water retention performance, reduces the occurrence of wrinkles, keeps the skin tender and smooth; and improves cell circulation. After NMN is applied to the face, the facial skin secretes collagen, hyaluronic acid, elastic fibers and other substances to tighten the skin, brighten the skin, lighten pigmentation, and repair sensitive skin damage caused by air pollution, ultraviolet radiation, etc.

NMN supplementation restores olfactory function

In February 2023, Professor Vilhelm A. Bohr's team from the National Institute on Aging published an article titled "Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice" in the journal Aging Cell. .

The study found that olfactory dysfunction may be a more sensitive early biomarker of aging than memory and motor behavior impairment, and NAD + supplementation can restore the sense of smell and extend lifespan in aged mice.

Nicotinamide mononucleotide (NMN) is a physiologically circulating nicotinamide adenine dinucleotide (NAD+) precursor. Supplementing NMN can increase the cellular level of NAD+.

NMN has significant fat reduction effect

There have been many studies on NMN helping weight management in the past, and a 2023 study by Shizuoka University in Japan further revealed the fat reduction principle of NMN: NMN can significantly reduce the amount of subcutaneous fat and the size of adipocytes.

Specifically:

Decreased adipose triglyceride lipase (ATGL) leads to increased fat mass;

NMN induces lipolysis by regulating ATGL expression through the SIRT1-AMPK axis in adipocytes;

NMN can significantly reduce the amount of subcutaneous fat and reduce the size of adipocytes in mice fed a high-fat diet.

NMN helps stem cells resist aging

Stem cells have always been famous in the field of anti-aging, and NMN, as a rising star in the anti-aging field, is also known as "edible stem cells." In 2023, research from the State Key Laboratory of Bioreactor Engineering at East China University of Science and Technology found that the powerful combination of NMN and stem cells will bring better results.

Human umbilical cord mesenchymal stem cells (hUC-MSCs) are widely used in the clinical treatment of degenerative diseases, metabolic diseases, and inflammatory diseases. However, the microenvironment of inflammatory tissue may cause oxidative stress in transplanted hUC-MSCs and induce senescence, thereby reducing the proliferation and migration capabilities of stem cells and affecting the final therapeutic effect.

After NMN treatment, it promoted the growth of stem cells, reduced reactive oxygen species (ROS) levels, prevented stem cells from entering a senescent state (dysfunctional pro-inflammatory state), and NMN increased stem cell migration by 3 times (helping stem cells to localize to specific organization plays a role). These results indicate that NMN is likely to become a golden partner for stem cell therapy and anti-aging.

1.Belongs to Vitamin B, participating in metabolism in the body, can be used to prevent pellagra or other niacin defection disease.

2.Could be used as feed/human nutrition, booth the growth and strengthen the immunity.

3.Play an important role in the production of human cell energy, which is involved in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion).

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